{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:08:32Z","timestamp":1753862912303,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Acute chest pain can be the first manifestation of multiple endocrine neoplasia type 1(MEN1)\u2010associated thymic neuroendocrine neoplasms (NEN). Comprehensive treatment may be an effective strategy for MEN1\u2010associated NEN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Multiple endocrine neoplasia type 1(MEN1)\u2010associated thymic neuroendocrine neoplasms (NEN) is caused by the mutation of tumor suppressor <jats:italic>MEN1<\/jats:italic> gene. Patients with MEN1\u2010associated NEN initially presenting with acute chest pain are very rare. In the manuscript, we reported a case of a 45\u2010year\u2010old man who developed MEN1\u2010associated NEN with acute chest pain as initial symptom. Thoracoscopic thymotomy was performed and thymic NEN was successfully removed. Genetic test showed a germline mutation of <jats:italic>MEN1<\/jats:italic> gene in this patient. Immunohistochemical staining exhibited Syn(+), CgA(+), INSM1(+), CD56(+) and Ki67\u2010positive cells (2%) in MEN1\u2010associated NEN. Further evaluation unveiled MEN1\u2010associated benign tumors including digestive NEN and pituitary gland adenoma. The 99mTc\u2010HYNIC\u2010TOC scintigraphy showed that focally increased radioactivity in the mid\u2010upper abdomen. This patient was administered with 50Gy\/25F of radiation dose to treat the postoperative lesions. Subsequently, sandostatin LAR (30\u2009mg per week) was used as systemic therapy. He had no recurrence or metastasis for 6\u2010month follow\u2010up. Thus, acute chest pain can be the first manifestation of MEN1\u2010associated NEN, and comprehensive treatment including surgery, radiation and systemic treatment may be an effective strategy for MEN1\u2010associated NEN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.9031","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:51:00Z","timestamp":1718351460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful management of a multiple endocrine neoplasia type 1\u2010associated thymic neuroendocrine neoplasms with acute chest pain as initial symptom: A rare case report"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0880-7690","authenticated-orcid":false,"given":"Xuesong","family":"Li","sequence":"first","affiliation":[{"name":"School of Clinical Medicine Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangbiao","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolism Beijing Tsinghua Changgung Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolism Beijing Tsinghua Changgung Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Beijing Tsinghua Changgung Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolism Beijing Tsinghua Changgung Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenxiang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolism Beijing Tsinghua Changgung Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00468-3"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021314"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000526775"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1155"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.12.032"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(02)03547-6"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0290-1"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.07.050"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.1.141"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181dd4ec4"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-018-0669-7"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14572"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-022-00613-1"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-20-0340"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.01200"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.9031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T06:41:19Z","timestamp":1720680079000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.9031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/ccr3.9031"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.9031","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2024-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9031"}}