{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:24:51Z","timestamp":1785205491692,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>In countries like Sudan, where several infectious diseases are prevalent, health care providers should not be satisfied with initial detection of a single pathogen and whenever it is feasible, they should investigate coinfections. Infections with high mortality or severe morbidity should be prioritized during the differential diagnosis particularly for diseases with similar clinical manifestations to reduce the death and disability rates. However, this requires substantial improvement in the diagnostic capacity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Here we report a case of dengue and malaria coinfection from the southeast region of Sudan, bordering Ethiopia and Eritrea. A 25\u2010year\u2010old male from Sudan presented with symptoms of fever, chills, vomiting, and muscle and joint pain. Laboratory investigations confirmed a coinfection of dengue and malaria, which is assumingly not uncommon in areas heavily syndemic with several diseases but it is severely under\u2010detected, underreported, and underestimated. The case has fully recovered after the supportive care for dengue and chemotherapy treatment for malaria. In such a case, it was important to monitor the patient's recovery and the treatment outcome through clinical indicators and laboratory parameters to update the treatment course whenever needed, according to response. The increasing burden and outbreaks of vector\u2010borne diseases including dengue and malaria in Sudan, indicates the need for improving the implementation of the global vector control response that established by the World Health Organization. Additionally, the increasing prevalent of coinfections is urging substantial improvement in the diagnostic capacity in endemic countries.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.9079","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T03:50:08Z","timestamp":1718164208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Severe coinfection of dengue and malaria: A case report"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6314-7374","authenticated-orcid":false,"given":"Emmanuel Edwar","family":"Siddig","sequence":"first","affiliation":[{"name":"Faculty of Medical Laboratory Sciences University of Khartoum  Khartoum Sudan"},{"name":"Department of Medical Microbiology and Infectious Diseases ErasmusMC, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6843-3361","authenticated-orcid":false,"given":"Nouh Saad","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Molecular Biology Unit Sirius Training and Research Centre  Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9516-9508","authenticated-orcid":false,"given":"Ayman","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute (Swiss TPH)  Allschwil Switzerland"},{"name":"Faculty of Science University of Basel  Basel Switzerland"},{"name":"Institute of Endemic Diseases University of Khartoum  Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-2327.82821"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/omcr\/omac022"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-16706-1"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.05.052"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.7926"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-022-04157-y"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(22)00039-8"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.JJID.2018.267"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed5030120"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/inthealth\/ihz122"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911802"},{"issue":"10","key":"e_1_2_12_13_1","first-page":"53","article-title":"Dengue: a review","volume":"94","author":"Rodriguez\u2010Tan RS","year":"1998","journal-title":"Tex Med"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2022.199018"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12010081"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.onehlt.2020.100188"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2511.181766"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008918"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003239"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed4010043"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10070885"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2542-5196(20)30269-2"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-019-4608-2"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joclim.2021.100057"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtb.2016.05.008"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011660"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-11-142"},{"key":"e_1_2_12_28_1","unstructured":"Sudan: Humanitarian Update 23 August 2023 [EN\/AR] \u2013 Sudan.2023ReliefWeb. 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