{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:29Z","timestamp":1753862849495,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["23JRRA0978"],"award-info":[{"award-number":["23JRRA0978"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Heavy\u2010chain deposition disease (HCDD), a rare monoclonal immunoglobulin deposition disease, involves truncated heavy\u2010chain deposition in kidneys. Limited long\u2010term data exist. We report a case of renal and cardiac failure with favorable outcomes post bortezomib\u2010based therapy. Stable renal function observed over 4\u2009years suggests efficacy in HCDD with multisystem involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Heavy\u2010chain deposition disease (HCDD) is an extremely rare form of monoclonal immunoglobulin deposition disease (MIDD) that involves the deposition of truncated immunoglobulin heavy chains in the kidneys. Only a few cases of HCDD with a favorable long\u2010term renal prognosis have been reported, resulting in limited long\u2010term follow\u2010up data for this patient population. In this report, we present the case of a 52\u2010year\u2010old patient with nephrotic syndrome who experienced renal failure and cardiac failure. Renal biopsy confirmed the presence of \u03b33\u2010HCDD and monoclonal Immunoglobulin G (IgG)\u03ba in the serum. The patient exhibited low voltage on electrocardiogram (ECG) and unexplained left ventricular hypertrophy on cardiac ultrasound. The patient underwent eight cycles of bortezomib\u2010based chemotherapy, which led to hematological remission. After 4\u2009years of follow\u2010up, the patient's renal function remained stable, with serum creatinine levels ranging from 0.7 to 0.9\u2009mg\/dL and proteinuria of 0.3\u20130.5\u2009g\/24\u2009h. Our findings suggest that bortezomib\u2010based chemotherapy is equally effective in HCDD patients with combined multisystem damage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.9091","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T10:19:04Z","timestamp":1720001944000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010term renal survival of \u03b33\u2010heavy\u2010chain deposition disease complicated by heart failure: A case report"],"prefix":"10.1002","volume":"12","author":[{"given":"Shujun","family":"Shi","sequence":"first","affiliation":[{"name":"Renal Division, Department of Medicine Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9389-8387","authenticated-orcid":false,"given":"Kaiying","family":"He","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine Lanzhou University Second Hospital  Lanzhou China"},{"name":"Lanzhou University  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaojun","family":"Liang","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuling","family":"Yue","sequence":"additional","affiliation":[{"name":"Guangzhou KingMed Center for Clinical Laboratory  Guangzhou Guangdong 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