{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:06:49Z","timestamp":1788527209287,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Infections in infantile hemangiomas (IHs) are generally limited, and only few cases have been reported. The rapid expansion of an ulcerated IH should raise concern for possible complications to monitor and provide immediate therapeutic interventions. This case highlights the importance of prompt treatment in large segmental IHs to prevent ulceration and related complications, including bleeding and superinfection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>IH is a benign tumor proliferating during early infancy. While many IHs spontaneously resolve, complications like ulceration, bleeding, and potential damage to vital organs can occur, leading to pain, infection, and scarring. A 6\u2010month\u2010old girl with a previously treated IH on her left leg developed a <jats:italic>Klebsiella<\/jats:italic>\u2010infected ulcer at the site. The ulcer resulted from non\u2010standard treatments used before admission. Upon hospitalization, she was initially treated with cefepime and propranolol, but a week later, the wound culture revealed <jats:italic>Klebsiella pneumoniae<\/jats:italic>, prompting a switch to piperacillin\/tazobactam. After successfully managing the infection and bleeding, the child was discharged in good condition with orders to continue treatment with propranolol for at least a year. This case highlights the potential of IHs to become infected even with uncommon germs such as Klebsiella and the importance of receiving appropriate medical care to prevent further complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.9149","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T10:35:04Z","timestamp":1720089304000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Klebsiella pneumoniae<\/i>\u2010infected hemorrhagic ulcerative infantile hemangioma: A rare complication"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1081-9477","authenticated-orcid":false,"given":"Bahareh","family":"Abtahi\u2010Naeini","sequence":"first","affiliation":[{"name":"Pediatric Dermatology Division of Department of Pediatrics, Imam Hossein Children's Hospital Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4462-2883","authenticated-orcid":false,"given":"Mahsa","family":"Pourmahdi\u2010Boroujeni","sequence":"additional","affiliation":[{"name":"Student Research Committee Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1321-7149","authenticated-orcid":false,"given":"Narjes","family":"Alipour","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7392-6547","authenticated-orcid":false,"given":"Hossein","family":"Sattari","sequence":"additional","affiliation":[{"name":"Clinical Research Development Center Najafabad Branch, Islamic Azad University  Najafabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5424-3919","authenticated-orcid":false,"given":"Zahra","family":"Pourmoghaddas","sequence":"additional","affiliation":[{"name":"Pediatrics Infectious Diseases Department Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"Pediatric Cardiovascular Research Center. Cardiovascular Research Institute Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3345\/cep.2020.02061"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.5114\/dr.2022.120178"},{"issue":"2","key":"e_1_2_14_4_1","first-page":"E17","article-title":"Using topical citric acid to treat an infected ulcerated hemangioma in an infant: a case study","volume":"33","author":"Nagoba B","year":"2021","journal-title":"Wounds"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04144-0"},{"key":"e_1_2_14_6_1","volume-title":"Medical Microbiology","author":"Baron S","year":"1996"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2022.10.037"},{"issue":"4","key":"e_1_2_14_8_1","first-page":"342","article-title":"Successful use of topical \"ankaferd blood stopper\" for repetitive bleedings in an infant with infantile hemangioma","volume":"5","author":"Annag\u00fcr A","year":"2012","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.750662"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-8-43"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1987.tb00748.x"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1993.tb01024.x"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.74.2.161"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63087-8"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.1999.00918.x"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-003-1334-4"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.12.009"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.324"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2018.01.013"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.3989"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/pxaa050"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.9149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T12:47:44Z","timestamp":1748350064000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.9149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/ccr3.9149"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.9149","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9149"}}