{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:52:10Z","timestamp":1776091930196,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T00:00:00Z","timestamp":1720310400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Rituximab\u2010induced serum sickness (RISS) is a rare complication of Rituximab (RTX) in immunobullous disorders. Clinicians should be aware of the occurrence of serum sickness symptoms during RTX administration, and prompt initiation of corticosteroid therapy is crucial in these patients. Additionally, RISS may occur with subsequent RTX doses and patients should be counseled accordingly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Rituximab (RTX) is a chimeric monoclonal anti\u2010CD20 antibody which has gained approval for the treatment of various autoimmune and lymphoproliferative disorders. While RTX\u2010induced minor reactions, including immediate infusion\u2010related reactions, are common, serum sickness is rare. Limited data exist regarding rituximab\u2010induced serum sickness (RISS) in pemphigus vulgaris (PV) and mucous membrane pemphigoid (MMP). We report two cases of RISS following RTX administration in PV and MMP patients. Both patients presented with typical symptoms of serum sickness after RTX infusion, necessitating drug cessation and corticosteroid therapy for resolution. RISS represents a rare complication of RTX therapy. Clinicians should maintain awareness of serum sickness presentations during and post\u2010RTX administration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.9152","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T06:15:24Z","timestamp":1720419324000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rituximab\u2010induced serum sickness in immunobullous disorders: A case series"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1268-7412","authenticated-orcid":false,"given":"Mehdi","family":"Gheisari","sequence":"first","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Dermatology, Loghman\u2010Hakim Hospital, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1417-5413","authenticated-orcid":false,"given":"Toktam","family":"Safari\u00a0Giv","sequence":"additional","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Dermatology, Loghman\u2010Hakim Hospital, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4069-7289","authenticated-orcid":false,"given":"Elnaz","family":"Pourgholi","sequence":"additional","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Dermatology, Loghman\u2010Hakim Hospital, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4002-6953","authenticated-orcid":false,"given":"Shirin","family":"Zaresharifi","sequence":"additional","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Department of Dermatology, Loghman\u2010Hakim Hospital, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.04.039"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2020.26.7.832"},{"key":"e_1_2_12_4_1","unstructured":"HanifN AnwerF.Rituximab.2020."},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00497-9"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61140-4"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.11.005"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu258"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198801000-00003"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13730-017-0297-7"},{"key":"e_1_2_12_11_1","first-page":"1","article-title":"Serum sickness following tetanus toxoid injection","volume":"2021","author":"Aldarwish M","year":"2021","journal-title":"Case Rep Pediatr"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00163"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2016.053"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.10.018"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00248"},{"key":"e_1_2_12_16_1","unstructured":"KarmacharyaP PoudelDR PathakR et\u00a0al.Rituximab\u2010induced serum sickness: a systematic review. Paper presented at: Seminars in arthritis and rheumatism20152015."},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2019.06.009"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.3642"},{"issue":"2","key":"e_1_2_12_19_1","first-page":"75","article-title":"Rituximab\u2010induced serum sickness in pemphigus vulgaris: a case report and literature review","author":"Jolie Krooks B","year":"2019","journal-title":"Pract Dermatol"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.863177"},{"issue":"67","key":"e_1_2_12_21_1","first-page":"2","article-title":"Rituximab induced acute respiratory distress syndrome (ARDS) reversed with plasmapheresis: case report","volume":"5","author":"Chakib C","year":"2021","journal-title":"PAMJ\u2010Clinical Medicine"},{"issue":"1","key":"e_1_2_12_22_1","first-page":"54","article-title":"Rituximab\u2010induced serum sickness in pemphigus vulgaris","volume":"15","author":"Awal G","year":"2018","journal-title":"JEWDS"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdd.ijdd_5_19"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-232896"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.9152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T12:48:24Z","timestamp":1748350104000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.9152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/ccr3.9152"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.9152","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9152"}}