{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:39Z","timestamp":1753862859998,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>As there is no significant mutual relationship between <jats:italic>Helicobacter pylori<\/jats:italic> infection and chronic kidney disease in children, its routine study is not justified and is recommended only in symptomatic cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Children suffering from chronic kidney disease (CKD) often complain of indigestion but, if it is accompanied by abdominal pain, it is necessary to investigate and rule out Helicobacter pylori infection to confirm functional dyspepsia. Epidemiological studies in adults have conflicting results regarding the association between <jats:italic>Helicobacter pylori<\/jats:italic> infection and CKD. In this study, we determined the prevalence of <jats:italic>H. pylori<\/jats:italic> in children with kidney failure and its relationship to their gastrointestinal symptoms. In this retrospective study, 54 children with chronic kidney failure admitted to the hemodialysis ward of the Children's Medical Center, Tehran, Iran between 2012 and 2020 were studied. The mean age of our patients was 11.89\u2009\u00b1\u20093.99\u2009years and their sex distribution was equal. <jats:italic>H. pylori<\/jats:italic> infection was reported in only three patients with 5.6%. Based on our findings, epigastric pain in children was the most common gastrointestinal symptom (70.4%). Among all patients, three patients (5.6%) died, all of them were male (P\u2009=\u20090.075). The most prevalent underlying cause of kidney failure in our patients was neurogenic bladder. We did not find any significant relationship between the increased risk of chronic kidney failure and co\u2010infection with <jats:italic>H. pylori<\/jats:italic>. Investigating the cause of epigastric pain and looking for <jats:italic>H. pylori<\/jats:italic> is very important in CKD children under hemodialysis because if they receive a transplant the possibility of gastrointestinal complications will be increased with the use of steroid and immunosuppressive drugs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.9157","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T09:55:02Z","timestamp":1720000502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determining the frequency of <i>Helicobacter pylori<\/i> in children with chronic kidney failure and its relationship to gastrointestinal symptoms"],"prefix":"10.1002","volume":"12","author":[{"given":"Behgol Nemati","family":"Nezhad","sequence":"first","affiliation":[{"name":"Resident of Pediatric Course, Children Medical Center Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahar","family":"Allahverdi","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Research Center, Children's Medical Center, The Pediatric Center of Excellence Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzaneh","family":"Motamed","sequence":"additional","affiliation":[{"name":"Pediatric GI Research Center, Children's Medical Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirin","family":"Djalalinia","sequence":"additional","affiliation":[{"name":"Deputy of Research and Technology Ministry of Health and Medical Education  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahimeh","family":"Askarian","sequence":"additional","affiliation":[{"name":"Pediatric Chronic Kidney Diseases Research Center, Children's Medical Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daryoush","family":"Fahimi","sequence":"additional","affiliation":[{"name":"Pediatric Chronic Kidney Diseases Research Center, Children's Medical Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behnaz","family":"Bazargani","sequence":"additional","affiliation":[{"name":"Pediatric Chronic Kidney Diseases Research Center, Children's Medical Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Pediatric Chronic Kidney Diseases Research Center, Children's Medical Center Tehran University of Medical Sciences  Tehran 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pylori infection in renal failure patients","volume":"2","author":"Ardalan MR","year":"2016","journal-title":"Immunopathologia Persa"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13928"},{"issue":"2","key":"e_1_2_13_19_1","first-page":"124","article-title":"Helicobacter pylori infection in pediatric candidates for kidney transplantation","volume":"5","author":"Hooman N","year":"2011","journal-title":"Iran J Kidney Dis"}],"container-title":["Clinical Case 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