{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:49:21Z","timestamp":1789206561429,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Key Clinical Message<\/jats:title>\n                    <jats:p>The precise management of hypersensitivity reactions to direct oral anticoagulants (DOACs) and the potential for cross\u2010reactivity among different DOACs remain unclear. In such cases, switching between DOACs may be feasible and could be considered, but close monitoring for adverse effects is essential, tailored to individual patient responses and tolerability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Hypersensitivity reactions to DOACs, though considered rare, have been documented. This report describes the case of a 28\u2010year\u2010old male with a history of testicular cancer who was recently diagnosed with deep vein thrombosis. He was referred to an outpatient pharmacotherapy clinic due to suspected rivaroxaban\u2010induced cutaneous reactions. Following a thorough evaluation, his anticoagulant therapy was switched from rivaroxaban to apixaban. This change was successfully implemented, and no hypersensitivity symptoms recurred during subsequent follow\u2010up. This case demonstrates the importance of recognizing potential adverse reactions to DOACs and illustrates the feasibility of switching anticoagulants under close medical supervision to ensure patient safety and effective treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccr3.9213","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T02:40:51Z","timestamp":1721788851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hypersensitivity reaction to rivaroxaban with a successful switch to apixaban: A case report"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7699-8538","authenticated-orcid":false,"given":"Keyhan","family":"Mohammadi","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy Tehran University of Medical Sciences  Tehran Iran"},{"name":"Research Center for Antibiotic Stewardship and Antimicrobial Resistance, Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakila","family":"Yaribash","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-023-01428-y"},{"key":"e_1_2_12_3_1","first-page":"181","article-title":"Anti\u2010Xa inhibitor\u2010induced hemorrhagic pruritic rash: a case report on possible cross\u2010reactivity between apixaban and rivaroxaban","volume":"13","author":"Anis TR","year":"2021","journal-title":"Clin Pharmacol"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009638"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2020.06.015"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01204.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp160985"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.24911\/ejmcr\/173-1555632293"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098620937884"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.5070\/D32610050473"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2016.03.012"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/FAD.0000000000000045"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2021.07.022"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2015.12.021"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12013"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2021.38.333.28401"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1649507"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.14740\/jmc3399"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S413057"},{"issue":"1","key":"e_1_2_12_21_1","first-page":"38","article-title":"Delayed hypersensitivity to new oral anticoagulants. Demonstration of cross reactivity for the drug category and definition of non\u2010irritant concentrations for patch tests","volume":"51","author":"Cortellini G","year":"2019","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxaa182"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr3394w"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.12.007"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.23822\/EurAnnACI.1764-1489.309"},{"issue":"8","key":"e_1_2_12_26_1","article-title":"Cutaneous Leukocytoclastic Vasculitis induced by apixaban and\/or rivaroxaban with seronegative anti\u2010neutrophil cytoplasmic antibody (ANCA) titers: a case report and literature review","volume":"15","author":"El\u2010Sabbagh M","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0897190017722872"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp140549"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.603"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.RV17005"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029619847524"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjac039"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017559"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12185955"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.9213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:26:30Z","timestamp":1726273590000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.9213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,23]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/ccr3.9213"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.9213","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.172445170.03614189\/v1","asserted-by":"object"}]},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,23]]},"assertion":[{"value":"2024-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9213"}}