{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:08:45Z","timestamp":1793750925158,"version":"4.6.1"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Clinical Key Message<\/jats:title><jats:p>In patients receiving anti\u2010TNF\u2010\u03b1 drugs for ankylosing spondylitis, monitoring purpuric and ischemic skin lesions is crucial. This case underscores the significance of identifying and addressing drug\u2010induced vasculitis while stressing the necessity for prompt evaluation and exploration of alternative treatment options to safeguard patient well\u2010being.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>The case discusses a 38\u2010year\u2010old female with a history of ankylosing spondylitis (AS) who presented with skin lesions, including purpuric skin lesions and ischemia of her right foot digits, after initiating treatment with adalimumab. After excluding other potential causes, such as infections and malignancies, the patient received a diagnosis of moderate\u2010sized vascular vasculitis associated with adalimumab use. Discontinuation of adalimumab and treatment with high dose glucocorticoids and intravenous pulse of cyclophosphamide resulted in the resolution of her ischemic lesions. This case underscores the importance of considering drug\u2010related side effects in patients with new skin lesions, particularly in the context of rheumatic diseases such as AS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.9244","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T02:38:51Z","timestamp":1723084731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adalimumab\u2010induced leukocytoclastic vasculitis in a patient with ankylosing spondylitis: A case report"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-6967","authenticated-orcid":false,"given":"Alireza","family":"Khabbazi","sequence":"first","affiliation":[{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences  Tabriz 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