{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:24:15Z","timestamp":1790270655582,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Primary hyperaldosteronism with type 3 autoimmune polyendocrine syndrome was a rare combination of both hyper\u2010 and hypoendocrine gland function. Comprehensive treatment including surgery and replacement therapy might be an effective strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Primary aldosteronism (PA) is a common cause of secondary hypertension originating from hormones. Type 3 autoimmune polyendocrine syndrome (APS\u20103) is characterized by the simultaneous or subsequent occurrence of autoimmune\u2010mediated endocrine gland damage, except for Addison disease. Here we reported an extremely rare case of a 63\u2010year\u2010old woman with PA and APS\u20103 who initially presented with hypertension (HT). The APS\u20103 of this patient mainly exhibited type 1 diabetes mellitus (T1DM) and Hashimoto's thyroiditis. She underwent the adrenal adenoma resection with a histopathologic diagnosis of adrenal cortical adenoma. After surgery, the HT of this patient was immediately reversed, and the concentration of serum potassium went back to normal. Then, this patient was administered with replacement therapy of insulin and levothyroxine sodium tablets (L\u2010T4).<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.9256","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T10:30:26Z","timestamp":1722853826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Primary hyperaldosteronism associated with type 3 autoimmune polyendocrine syndrome: A rare case report"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0880-7690","authenticated-orcid":false,"given":"Xuesong","family":"Li","sequence":"first","affiliation":[{"name":"School of Clinical Medicine Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangbiao","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolism Beijing Tsinghua Changgung Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolism Beijing Tsinghua Changgung Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolism Beijing Tsinghua Changgung Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxiang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolism Beijing Tsinghua Changgung Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-022-03168-8"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-0880-2"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13074"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.853403"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834a4c75"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802886"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002300"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2032-6"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2008.03.003"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.5.1346"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1179"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2015.43"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12060918"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad654"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.9256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T04:29:31Z","timestamp":1726288171000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.9256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/ccr3.9256"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.9256","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9256"}}