{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:05:53Z","timestamp":1780481153420,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Creutzfeldt\u2010Jakob disease (CJD) is a rapidly progressive, fatal neurodegenerative disorder. This case highlights parkinsonism as a rare initial manifestation of sporadic CJD (sCJD), emphasizing the need for heightened clinical awareness to prevent misdiagnosis. Early and accurate diagnosis of sCJD is crucial for preventing potential iatrogenic transmission and optimizing patient management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Creutzfeldt\u2010Jakob disease (CJD) is a fatal neurodegenerative illness. While movement disorders may be present at the onset of the disease in about half of those with sporadic CJD (sCJD), parkinsonism is a rare initial presentation. In this article, we report a case of CJD with parkinsonism as the initial presentation of the disease. We report a 69\u2010year\u2010old lady with initial symptoms of gait difficulty, tremor, and bradykinesia. Later, she developed cognitive impairment, ataxia, chin tremor, and myoclonic jerks. Her condition worsened to the point of akinetic mutism. She was diagnosed with probable sCJD after detecting protein 14\u20103\u20103 in her cerebrospinal fluid and observing typical imaging features.This case report illustrates important aspects of an inevitably fatal and rapidly progressing disease's early presentation and clinical features. The uncommon initial presentations of sCJD should be considered with the intent of preventing misdiagnosis in the future. Early diagnosis of sCJD can prevent possible iatrogenic disease transmission and improve patient care.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.9278","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T07:53:46Z","timestamp":1723276426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Parkinsonism as an initial presentation of Creutzfeldt\u2010Jakob disease: A case report and review of literature"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9537-7000","authenticated-orcid":false,"given":"Sahar Nikkhah","family":"Bahrami","sequence":"first","affiliation":[{"name":"Student Research Committee, Tehran Medical Sciences Branch Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asal Sadat","family":"Karimi","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2764-8128","authenticated-orcid":false,"given":"Sepehr","family":"Khosravi","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine Iran University of Medical Sciences  Tehran Iran"},{"name":"Cognitive Neurology, Dementia and Neuropsychiatry Research Center (CNNRC) Tehran University of Medical Sciences (TUMS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3244-1615","authenticated-orcid":false,"given":"Mostafa","family":"Almasi\u2010Dooghaee","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine Iran University of Medical Sciences  Tehran 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