{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T01:11:51Z","timestamp":1780708311915,"version":"3.54.1"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Sarcoidosis is a systemic granulomatous disease with an unknown cause, marked by the presence of noncaseating granulomas in the affected organs. While the pulmonary interstitium is most frequently involved, the disease can affect almost any other organ system. Extrapulmonary involvement can occur with or without lung involvement, but isolated extrapulmonary involvement is a rare event. Isolated splenomegaly is very rare and presents an uncommon manifestation of sarcoidosis, its diagnoses is a challenge due to a broad differential diagnosis. Here, we present an intriguing case of a 28\u2010year\u2010old male with isolated splenic sarcoidosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Sarcoidosis is a systemic disease of unknown cause, marked by the presence of noncaseating granulomas in affected organs. It most frequently impacts the pulmonary interstitium, though it can also affect nearly any other organ system. This involvement can occur with or without lung involvement, but isolated extrapulmonary cases are observed in only about 10% of instances. Furthermore, isolated splenomegaly is an exceptionally rare event and an uncommon presentation of sarcoidosis, posing a significant clinical challenge due to the wide differential diagnosis. Potential differential diagnoses include hematologic cancers, primary or metastatic splenic tumors, infiltrative diseases, inflammatory conditions, and infections. We present a noteworthy case of a 28\u2010year\u2010old with isolated splenic sarcoidosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.9283","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T06:06:28Z","timestamp":1723010788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sarcoidosis presenting as isolated massive splenomegaly: A case report"],"prefix":"10.1002","volume":"12","author":[{"given":"Melissa","family":"Kyriakos\u00a0Saad","sequence":"first","affiliation":[{"name":"Saint George Hospital University Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imad","family":"El\u00a0Hajj","sequence":"additional","affiliation":[{"name":"Department of General Surgery Saint George Hospital University Medical Center, Saint George University of Beirut  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3187-4694","authenticated-orcid":false,"given":"Elias","family":"Saikaly","sequence":"additional","affiliation":[{"name":"Department of General Surgery Saint George Hospital University Medical Center, Saint George University of Beirut  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071714"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36517"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2012.03.019"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.37.449"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2005.15.160"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.182.1.1820015"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1399122"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01295-0"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sult.2006.10.004"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31815d8276"},{"issue":"1","key":"e_1_2_12_12_1","first-page":"37","article-title":"Atypical sarcoidosis: case reports and review of the literature","volume":"13","author":"Giovinale M","year":"2009","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"e_1_2_12_13_1","first-page":"66","article-title":"Splenectomy in sarcoidosis: indications, complications, and long\u2010term followup","volume":"19","author":"Sharma OP","year":"2002","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.9283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T04:24:25Z","timestamp":1726287865000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.9283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/ccr3.9283"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.9283","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9283"}}