{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:47Z","timestamp":1753862867520,"version":"3.41.2"},"reference-count":8,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,8]]},"abstract":"Key Clinical Message<\/jats:title>Early recognition and management of seronegative celiac disease, even in the absence of typical serological markers, can prevent complications and ensure better health outcomes in pediatric patients. Consideration of a gluten\u2010free diet in similar cases can lead to significant clinical improvement.<\/jats:p><\/jats:sec>Abstract<\/jats:title>Celiac disease, characterized by its diverse clinical manifestations, often necessitates adherence to a gluten\u2010free diet, particularly in pediatric patients for optimal growth and development. This report presents the case of an 11\u2010year\u2010old male who exhibited recurrent symptoms of fever and diarrhea progressing to edema and pallor, with a history dating back to age 3. Laboratory findings revealed pancytopenia, hypoalbuminemia, and proteinuria. Despite negative serological markers, noninvasive tests, along with clinical improvement on a gluten\u2010free diet and supportive measures within a month, suggested celiac disease complicated by transient protein\u2010losing enteropathy and vitamin B12 deficiency. It is important to note that other malabsorption disorders can also show clinical improvement following a gluten\u2010free diet. Additionally, the antibiotic treatment received by the patient could have addressed other possible causes of malabsorption, complicating the differential diagnosis. This case highlights the importance of early recognition and management of celiac disease, especially in pediatric patients, to prevent complications and promote optimal health outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.9297","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T06:11:43Z","timestamp":1723011103000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Seronegative celiac disease with transient protein\u2010losing enteropathy and vitamin B12 deficiency in a pediatric patient: Case report"],"prefix":"10.1002","volume":"12","author":[{"given":"Aisha","family":"Shaikh","sequence":"first","affiliation":[{"name":"Department of Pediatrics Civil Hospital Karachi, Dow University of Health Sciences Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saad","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Ahsan","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Zain\u2010Ul\u2010Haq","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hashim Talib","family":"Hashim","sequence":"additional","affiliation":[{"name":"College of Medicine Warith Al Anbiyaa University Karbala Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6959-1426","authenticated-orcid":false,"given":"Ali Talib","family":"Hashim","sequence":"additional","affiliation":[{"name":"Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9076-8220","authenticated-orcid":false,"given":"Ahmed Qasim Mohammed","family":"Alhatemi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Al\u00a0Nasiriyah Teaching Hospital Thi\u00a0Qar Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.06.037"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.131"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000436"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.12.010"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619844125"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.45"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.8574"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_1116_19"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.9297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T04:25:48Z","timestamp":1726287948000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.9297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":8,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/ccr3.9297"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.9297","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9297"}}