{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:35:46Z","timestamp":1780443346378,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Prompt diagnosis of tuberculous meningitis (TBM) is crucial to prevent severe complications like cranial nerve involvement and irreversible visual impairment. Early suspicion and intervention are essential, especially in tuberculosis\u2010endemic regions. Rapid initiation of anti\u2010tuberculosis therapy and vigilant monitoring for complications, such as hydrocephalus, improve patient outcomes and prevent long\u2010term disabilities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>This case study provides a comprehensive overview of the difficulties associated with predicting and managing tuberculous meningitis (TBM). The predictive aspect is hindered by the subacute nature of TBM, featuring a prodromal phase lasting 7\u201310\u2009days, followed by manifestations like severe headaches, altered mental status, stroke, hydrocephalus, and cranial neuropathies. Additionally, vision loss is a disabling complication. All components of the visual pathway, especially the optic nerve and optic chiasma, are frequently and dominantly affected. While antibiotics can promptly resolve meningitis in most cases, approximately 10% of infections progress to chronic meningitis, with tuberculosis meningitis being the most common form. Our patient initially presented with nonspecific symptoms, which later evolved into symptoms that indicate viral meningitis and was started on empirical therapy. Subsequently, due to clinical suspicion of tuberculosis meningitis and persistent symptoms despite treatment, she was placed in anti\u2010tuberculosis therapy (ATT) but unfortunately developed complications such as hydrocephalus and blindness. To address the hydrocephalus, a Ventriculo\u2010Peritoneal shunt was implanted. Despite delayed treatment and diagnosis, most of her symptoms resolved except for blindness, for which there was only partial recovery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.9334","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T04:14:11Z","timestamp":1724127251000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A case report of tuberculous meningitis resulting in irreversible visual impairment due to delayed diagnosis"],"prefix":"10.1002","volume":"12","author":[{"given":"Erika Lee\u2010Yu","family":"Lin","sequence":"first","affiliation":[{"name":"School of Medicine Xiamen University  Xiamen P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Anil","family":"Gulhane","sequence":"additional","affiliation":[{"name":"School of Medicine Xiamen University  Xiamen P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majety Sameer","family":"Kumar","sequence":"additional","affiliation":[{"name":"School of Medicine Xiamen University  Xiamen P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Teja","family":"Lakkamaneni","sequence":"additional","affiliation":[{"name":"Andhra Medical College Andhra University  Visakhapatnam Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7765-3034","authenticated-orcid":false,"given":"Prudhvi","family":"Lekkala","sequence":"additional","affiliation":[{"name":"Medical College Kyrgyz Russian Slavic University  Bishkek Kyrgyzstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"e_1_2_15_2_1","volume-title":"StatPearls [Internet]","author":"Slane VH","year":"2024"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jctube.2020.100145"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.332275"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jctube.2020.100164"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-021-02340-3"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70162-6"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac513"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/798764"},{"key":"e_1_2_15_10_1","volume-title":"Harrison's Principles of Internal Medicine","author":"Loscalzo J","year":"2022"},{"key":"e_1_2_15_11_1","unstructured":"AllanachS.Effects of hydrocephalus. n.d..https:\/\/hydrocephalus.allanach.dk\/effects."},{"key":"e_1_2_15_12_1","unstructured":"Hydrocephalus Association.Types of vision problems \u2010 hydrocephalus.2023. Available from:https:\/\/www.hydroassoc.org\/types\u2010of\u2010vision\u2010problems\u2010hydrocephalus\/"},{"key":"e_1_2_15_13_1","first-page":"3","volume-title":"Treatment of Tuberculosis: Guidelines","year":"2010"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.095620"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0279203"},{"key":"e_1_2_15_16_1","unstructured":"Schmid DanersM.Adaptive shunts for cerebrospinal fluid control (Doctoral dissertation Eidgen\u00f6ssische Technische Hochschule ETH Z\u00fcrich Nr. 20674).2012."},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.24015\/JAPM.2018.0092.9"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.9334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T04:26:25Z","timestamp":1726287985000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.9334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/ccr3.9334"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.9334","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9334"}}