{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:18:47Z","timestamp":1781651927508,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>LMS of IVC needs a multidisciplinary approach. Surgical excision with free margin is the cornerstone of management. Upon case\u2010by\u2010case selection, adjuvant chemotherapy may play a role in better oncologic outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Leiomyosarcoma (LMS) of the inferior vena cava (IVC) is a rare form of mesenchymal origin malignancy with less than 400 cases reported to date. Surgery is the mainstay of management but it requires vast experience in vascular and visceral surgery to attain a free tumor margin. Subsequent adjuvant treatment with chemotherapy and radiation remains as an area of gray zone. We report the case of a 61\u2010year\u2010old man with an 8\u2010month history of abdominal pain. Upon physical examination, an ill\u2010defined mass over the right side of the lower abdomen and bilateral lower extremity edema were detected. Abdominal ultrasound with Doppler revealed a right\u2010side retroperitoneal mass invading the IVC with extensive venous thrombosis for which anticoagulation was initiated. Computed Tomography of the abdomen revealed a huge heterogeneously enhancing mass involving the whole length of the infrarenal IVC obstructing the IVC lumen with collateral veins draining through the paralumbar veins and inferior epigastric veins bilaterally. With a top differential of primary IVC LMS, a midline longitudinal laparotomy was performed with an intraoperative finding of a tumor arising from the infra\u2010renal IVC which was excised. Gore\u2010Tex graft was used to reconstruct the IVC. There was an injury to the right common iliac artery and it was repaired by end\u2010to\u2010end anastomosis. Histopathology confirmed a high\u2010grade LMS of the IVC and surgical margin status was unknown. He was given adjuvant Chemotherapy consisting of Doxorubicin and Dacarbazine. He has been on follow\u2010up at the Oncology side with a good performance status.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.9336","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T01:22:05Z","timestamp":1724289725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Surgical and oncologic approach to leiomyosarcoma of the inferior vena cava: A case report"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5416-1488","authenticated-orcid":false,"given":"Feleke Hailmariam","family":"Maniso","sequence":"first","affiliation":[{"name":"Department of Clinical Oncology Tikur Anbessa Specialized Hospital, College of Health Science, Addis Ababa University  Addis Ababa Ethiopia"},{"name":"Oncology Unit, St. Paul's Hospital Millennium Medical College  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6452-8846","authenticated-orcid":false,"given":"Mathewos Assefa","family":"Woldegeorgis","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Tikur Anbessa Specialized Hospital, College of Health Science, Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5723-7274","authenticated-orcid":false,"given":"Hawi Furgassa","family":"Bedada","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Tikur Anbessa Specialized Hospital, College of Health Science, Addis Ababa University  Addis Ababa Ethiopia"},{"name":"Oncology Unit, St. Paul's Hospital Millennium Medical College  Addis Ababa 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