{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T18:07:01Z","timestamp":1770919621469,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec><jats:title>Key Clinical Message<\/jats:title><jats:p>Kawasaki disease (KD), a self\u2010limiting vasculitis, can present with a broader spectrum of vascular involvements, necessitating early recognition and prompt management. This case exemplifies the importance of involving multiple teams on board in managing complex presentations of KD. It also highlights the importance of close monitoring for the progression of the disease spectrum as well as family education to ensure favorable outcomes. The case also emphasizes the importance of long\u2010term follow\u2010up and further research to understand the prognosis, early screening tools, and possible complications due to multi\u2010organ involvement in KD along with their management strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p>Kawasaki disease (KD) is a multisystem vascular inflammatory syndrome, which predominantly affects the small and medium vessels in children within the age group of less than 5\u2009years. The most threatened complication is the development of coronary artery aneurysms (CAAs). We present an extremely rare case of KD in a 2\u2010month, 21\u2010day\u2010old male infant with extensive vascular involvement, expanding the disease spectrum beyond the involvement of coronary arteries. These included aneurysmal dilatations of both internal carotid arteries, the descending aorta, bilateral multilevel intercostal arteries, coeliac artery, superior mesenteric artery, and both renal arteries. Implementing a multidisciplinary approach with early treatment via intravenous immunoglobulin (IVIG) and dexamethasone proved to be most effective in the patient's management. Despite unique challenges such as severe coronary dilation and pseudomonas sepsis during the special care, the patient was stabilized and discharged after 11\u2009days of hospital stay, highlighting the importance of early prompt management and a centered approach to evaluate in a broader spectrum. This case emphasizes the importance of long\u2010term follow\u2010up and further research to understand the prognosis, early screening tools, and possible complications due to multi\u2010organ involvement in KD along with their management strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccr3.9415","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T04:15:17Z","timestamp":1725250517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Kawasaki disease with profound systemic vascular involvements: An insightful pediatric case"],"prefix":"10.1002","volume":"12","author":[{"given":"Naila","family":"Nadeem","sequence":"first","affiliation":[{"name":"Department of Radiology The Aga Khan University Hospital  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Nadeem","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Radiology The Aga Khan University Hospital  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Haseeb","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Radiology Quaid\u2010e\u2010Azam Medical College  Bahawalpur Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mallick Muhammad","family":"Zohaibuddin","sequence":"additional","affiliation":[{"name":"Department of Radiology The Aga Khan University Hospital  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Radiology The Aga Khan University Hospital  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faheemullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Main Campus Hospital  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9934-3887","authenticated-orcid":false,"given":"Hatem","family":"Eltaly","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Main Campus Hospital  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uffan","family":"Zafar","sequence":"additional","affiliation":[{"name":"Department of Radiology The Aga Khan University Hospital  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000484"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-023-01478-9"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.738850"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241813948"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.220002"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.94.6.1379"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-2254"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i28.10266"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.9415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T11:23:13Z","timestamp":1734002593000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.9415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":8,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/ccr3.9415"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.9415","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9415"}}