{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:49:49Z","timestamp":1764254989761,"version":"3.46.0"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Key clinical message<\/jats:title>\n                    <jats:p>Perrault syndrome (PRLTS) is an uncommon hereditary condition distinguished by ovarian failure in females and sensorineural hearing loss. Infertility can be the presenting problem for a serious disease. History and physical examination is very essential among infertile couples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Perrault syndrome (PRLTS) is an uncommon hereditary condition distinguished by ovarian failure in females and sensorineural hearing loss. This case presentation describes a 22\u2010year\u2010old female from Saudi Arabia with PRLTS. The patient presented with progressive bilateral hearing loss since childhood, impacting her academic achievement. Additionally, she experienced amenorrhea since the age of 18\u2009years, with previous investigations showing no hormonal imbalances. Other laboratory tests, including bone mineral density, kidney and liver function, electrolytes, and lipid profile, showed mostly normal results, except for a slightly abnormal lipid profile with low high\u2010density lipoprotein and high low\u2010density lipoprotein levels. This case highlights the challenges faced by individuals with PRLTS, specifically progressive hearing loss and gonadal dysfunction, leading to infertility. Further evaluation and management are warranted to address the patient's hearing impairment and fertility concerns, with a multidisciplinary approach involving audiology, endocrinology, and reproductive medicine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccr3.9522","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T03:38:42Z","timestamp":1730691522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Perrault syndrome: a forgotten presentation for infertile women"],"prefix":"10.1002","volume":"12","author":[{"given":"Manal","family":"Alkhonezan","sequence":"first","affiliation":[{"name":"College of Medicine Imam Mohammad Ibn Saud Islamic University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahad","family":"Alkhonezan","sequence":"additional","affiliation":[{"name":"College of Medicine Imam Mohammad Ibn Saud Islamic University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3612-8199","authenticated-orcid":false,"given":"Dania","family":"Al\u2010Jaroudi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, King Fahad Medical City Riyadh Second Health Cluster  Riyadh Saudi Arabia"},{"name":"Reproductive Endocrine and Infertility Medicine Department, King Fahad Medical City Riyadh Second Health Cluster  Riyadh Saudi 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a systematic approach to diagnosis and management","volume":"100","author":"Klein DA","year":"2019","journal-title":"Am Fam Physician"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.29214"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2019.1637407"},{"key":"e_1_2_13_22_1","first-page":"79","article-title":"Two cases of turner syndrome with deaf\u2010mutism in two sisters","volume":"67","author":"Perrault M","year":"1951","journal-title":"Bull Mem Soc Med Hop Paris"}],"container-title":["Clinical Case 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