{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T10:12:25Z","timestamp":1772187145167,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Key Clinical Message<\/jats:title>\n                    <jats:p>Odontogenic carcinosarcoma, a rare and challenging diagnosis, was identified in a 60\u2010year\u2010old male through histopathology, revealing a biphasic neoplasm with malignant epithelial and mesenchymal components. Surgical resection is crucial for management, highlighting the importance of vigilant postoperative follow\u2010up to ensure early detection of any recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>One rare mixed malignant odontogenic tumor is odontogenic carcinosarcoma, which comprises malignant epithelial and mesenchymal components. Diagnosing odontogenic carcinosarcoma is challenging due to its rarity and atypical clinical presentation. This study reports a 60\u2010year\u2010old male patient who presented with a painless swelling on the right side of his face and experienced facial asymmetry for 6\u2009months, ultimately diagnosed with odontogenic carcinosarcoma. A biphasic neoplasm with malignant alterations in both epithelial and mesenchymal components was identified upon histopathological examination. MRI imaging showed an expansile multilobulated lytic lesion with cortical erosion and extraosseous extension in the posterior region of the right mandibular body and ramus. Following contrast administration, homogeneous lesion enhancement was observed, with a few small non\u2010enhancing necrotic areas in central parts. The patient subsequently underwent a right hemi\u2010mandibulectomy with resection of adjacent soft tissues and neck dissection due to lymph node involvement. The resulting defect was reconstructed using a pectoralis major flap. No recurrence or metastasis was reported during the 6\u2010month follow\u2010up, reinforcing the positive results. This case highlights the importance of recognizing odontogenic carcinosarcoma and underscores the challenges in diagnosing and managing this rare tumor. Early identification and aggressive treatment can lead to positive outcomes, as evidenced by the absence of recurrence or metastasis in this patient during the follow\u2010up period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccr3.9554","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T22:44:58Z","timestamp":1731365098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Odontogenic carcinosarcoma of the mandible: A case report"],"prefix":"10.1002","volume":"12","author":[{"given":"Pouyan","family":"Aminishakib","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Vice\u2010Head for International Affairs, School of Dentistry Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzaneh","family":"Mosavat","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Faculty of Dentistry Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6133-4894","authenticated-orcid":false,"given":"Mahsa","family":"Bayati","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Faculty of Dentistry Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ata","family":"Garajei","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Faculty of Dentistry Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-017-2182-3"},{"issue":"3","key":"e_1_2_13_3_1","first-page":"10","article-title":"Odontogenic tumors: where are we in 2017?","volume":"51","author":"Wright JM","year":"2017","journal-title":"J Istanbul Univ Fac Dent"},{"issue":"2","key":"e_1_2_13_4_1","first-page":"168","article-title":"The World Health Organization classification of odontogenic lesions: a summary of the changes of the 2022 (5th) edition","volume":"38","author":"Soluk\u2010Tekkesin M","year":"2022","journal-title":"Turk J Pathol"},{"issue":"1","key":"e_1_2_13_5_1","first-page":"84","article-title":"Malignant mixed tumor (malignant ameloblastoma and fibrosarcoma) of the maxilla","volume":"115","author":"Tanaka T","year":"1991","journal-title":"Arch Pathol Lab Med"},{"issue":"2","key":"e_1_2_13_6_1","first-page":"419","article-title":"Odontogenic carcinosarcoma of the mandible, a case report","volume":"23","author":"Abadi AR","year":"2022","journal-title":"J Dent"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2015.41.3.139"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.08.017"},{"key":"e_1_2_13_9_1","first-page":"603","article-title":"Case report: odontogenic carcinosarcoma arising from premature odontoma with immunohistochemical profile","volume":"9","author":"Salem HMWM","year":"2020","journal-title":"F1000Research"},{"issue":"3","key":"e_1_2_13_10_1","first-page":"267","article-title":"Odontogenic carcinosarcoma of the mandible: a case report","volume":"15","author":"Tahsino\u011flu M","year":"2013","journal-title":"J Istanbul Univ Fac Dent"},{"key":"e_1_2_13_11_1","unstructured":"SlaterLJ.Odontogenic sarcoma and carcinosarcoma. Seminars in diagnostic pathology.1999."},{"issue":"2","key":"e_1_2_13_12_1","first-page":"124","article-title":"Mandibular odontogenic carcinosarcoma: a case report","volume":"103","author":"Slama A","year":"2002","journal-title":"Rev Stomatol Chir Maxillofac"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2003.09.010"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.02.025"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2010.05.071"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2018.05.013"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896919888578"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605211045555"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.jomfp_408_20"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-023-01545-x"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_318_18"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12622"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.9554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:45:39Z","timestamp":1764254739000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.9554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/ccr3.9554"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.9554","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9554"}}