{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:32:12Z","timestamp":1780338732236,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Primary intimal sarcoma of the pulmonary artery is a rare and aggressive malignancy that presents significant diagnostic and therapeutic challenges due to its nonspecific symptoms and propensity for late detection. This case report aimed to elucidate the diagnostic journey, surgical intervention, and multidisciplinary management of this rare entity. In September 2023, a 42\u2010year\u2010old male presented with dyspnea on exertion and retrosternal chest pain, classified as NYHA FC II. Initial investigations, including ECG and lab tests, indicated tachycardia and elevated troponin and NT\u2010pro\u2010BNP levels. Transthoracic and transesophageal echocardiography identified a multilobulated mass in the right ventricular outflow tract and main pulmonary artery. Cardiac MRI and CT angiography confirmed a high\u2010grade pleomorphic spindle cell tumor, leading to surgical resection in October 2023. Histopathology confirmed intimal sarcoma. Postsurgery, the patient underwent chemotherapy and radiotherapy, showing significant clinical improvement and no recurrence on follow\u2010up PET\u2010CT. This case highlights the importance of a multidisciplinary approach in diagnosing and managing primary intimal sarcoma of the pulmonary artery, emphasizing the role of advanced imaging, timely surgical intervention, and combined chemotherapy with radiotherapy in improving patient outcomes.<\/jats:p>","DOI":"10.1002\/ccr3.9580","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:40:16Z","timestamp":1731976816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Comprehensive Insight Into Primary Intimal Sarcoma of the Pulmonary Artery; From Diagnosis to Management: A Case Report and Review of the Literature"],"prefix":"10.1002","volume":"12","author":[{"given":"Azin","family":"Alizadehasl","sequence":"first","affiliation":[{"name":"Cardio\u2010Oncology Research Center Rajaie Cardiovascular Medical and Research Institute  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soroush","family":"Najdaghi","sequence":"additional","affiliation":[{"name":"Heart Failure Research Center, Cardiovascular Research Institute Isfahan University of Medical Science  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Mohseni Salehi","sequence":"additional","affiliation":[{"name":"Cardio\u2010Oncology Research Center Rajaie Cardiovascular Medical and Research Institute  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahla","family":"Meshgi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Imaging, Rajaie Cardiovascular Medical and Research Center, School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedeh Fatemeh","family":"Hosseini Jebelli","sequence":"additional","affiliation":[{"name":"Cardio\u2010Oncology Research Center Rajaie Cardiovascular Medical and Research Institute  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azam","family":"Yalameh Aliabadi","sequence":"additional","affiliation":[{"name":"Cardio\u2010Oncology Research Center Rajaie Cardiovascular Medical and Research Institute  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda","family":"Hakimian","sequence":"additional","affiliation":[{"name":"Cardio\u2010Oncology Research Center Rajaie Cardiovascular Medical and Research Institute  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Forati","sequence":"additional","affiliation":[{"name":"Cardio\u2010Oncology Research Center Rajaie Cardiovascular Medical and Research Institute  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amineh","family":"Safavirad","sequence":"additional","affiliation":[{"name":"Cardio\u2010Oncology Research Center Rajaie Cardiovascular Medical and Research Institute  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delaram","family":"Narimani Davani","sequence":"additional","affiliation":[{"name":"Heart Failure Research Center, Cardiovascular Research Institute Isfahan University of Medical Science  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2020.102889"},{"key":"e_1_2_12_3_1","article-title":"A Journey From Cardiology to Oncology Reveals a Rare Case of Primary Intimal Sarcoma in a Patient With Dyspnea: A Case Report","volume":"15","author":"Mahdi A.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2021.101414"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.530"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000476036"},{"key":"e_1_2_12_7_1","first-page":"638","article-title":"Surgical Treatment of Primary Pulmonary Artery Sarcoma. 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