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The patient was diagnosed with a cholesterol crystal embolism. Treatment with prednisolone and rosuvastatin was initiated; however, no improvements were observed in the patient's cutaneous symptoms or renal function. Therefore, we decided to treat the patient with a new low\u2010density lipoprotein apheresis device (Rheocarna; Kaneka Corporation, Osaka, Japan). Following therapy, the lower extremity symptoms improved, and although dialysis was temporarily initiated, it was eventually discontinued.<\/jats:p>","DOI":"10.1002\/ccr3.9608","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T21:23:37Z","timestamp":1732137817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rheocarna Effectively Treats Oral Medicinal Therapy\u2010Resistant Cutaneous Symptoms and Renal Failure Induced by Cholesterol Crystal Embolism"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5989-6006","authenticated-orcid":false,"given":"Akinori","family":"Satake","sequence":"first","affiliation":[{"name":"Department of Cardiology Narita Memorial Hospital  Toyohashi Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Tokuda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya Heart Center  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aichi Medical University  Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aichi Medical University  Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Aichi Medical University  Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aichi Medical University  Nagakute Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.886465"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441\u2010200605000\u201000010"},{"key":"e_1_2_12_4_1","first-page":"456","article-title":"Efficacy of LDL Apheresis for the Treatment of Cholesterol Crystal Embolism: A Prospective, Controlled Study","volume":"1","author":"Ishiyama K.","year":"2021","journal-title":"Therapeutic Apheresis and Dialysis"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050313X221149359"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.2917\u201023"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744\u20109987.13915"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744\u20109987.13991"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744\u20109987.13891"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3400\/avd.oa.11.00022"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.10.045"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3400\/avd.AVDoa08029"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s101570300010"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000109101"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.61186\/wjps.12.3.106"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.9608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T14:45:49Z","timestamp":1764254749000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.9608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/ccr3.9608"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.9608","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9608"}}