{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:08:34Z","timestamp":1753862914953,"version":"3.41.2"},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Sclerosing adenosis (SA) is a subtype of adenosis characterized by proliferative adenosis and stromal sclerosis with distortion of the terminal ductal lobular unit. Although SA is the most prevalent benign breast condition among middle\u2010aged women, it may be associated with a two\u2010fold increase in breast cancer risk. Microscopic findings of ductal carcinoma in\u00a0situ (DCIS) in a SA (SA\u2010DCIS) may mimic microinvasive carcinoma or even invasive carcinoma, which may result in overtreatment by a breast surgeon. Therefore, pathological evaluation must be performed carefully in such cases to establish a definitive diagnosis. Herein, we present a rare case of SA\u2010DCIS that mimicked microinvasive ductal carcinoma. A 51\u2010year\u2010old woman was diagnosed with high\u2010grade DCIS of the left breast, highly suspicious for microinvasion, based on core biopsy. She underwent mastectomy of the left breast and prophylactic mastectomy of the right breast for personal reasons after imaging evaluation, including mammography and ultrasonography. However, the final diagnosis was bilateral intermediate\u2010grade DCIS, characterized by the presence of intraductal carcinoma cells exhibiting enlarged hyperchromatic nuclei and a high nuclear\u2010to\u2010cytoplasmic ratio within the mammary ducts. However, the diagnosis was incompatible with the initial pathological results. A\u2010DCIS has pathological features similar to those of microinvasive or invasive carcinomas. Thoroughly evaluating biopsy findings of lesions to distinguish between SA\u2010DCIS and invasive carcinoma is crucial to prevent overdiagnosis and unnecessary management in patients with DCIS. Patients diagnosed with SA\u2010DCIS are at a higher risk of developing bilateral breast cancer than those without SA\u2010DCIS.<\/jats:p>","DOI":"10.1002\/ccr3.9639","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T06:40:58Z","timestamp":1734072058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ductal Carcinoma In\u00a0Situ of the Breast in Sclerosing Adenosis Mimicking Microinvasive Ductal Carcinoma: A\u00a0Rare Case Report"],"prefix":"10.1002","volume":"12","author":[{"given":"Yu\u2010Kai","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Surgery Tri\u2010Service General Hospital, National Defense Medical Center  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan\u2010Yuei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Tri\u2010Service General Hospital, National Defense Medical Center  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Jie","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Traumatology, Department of Surgery Tri\u2010Service General Hospital, National Defense Medical Center  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo\u2010Shiou","family":"Liao","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery Tri\u2010Service General Hospital, National Defense Medical Center  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8298-0790","authenticated-orcid":false,"given":"Jyh\u2010Cherng","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery Tri\u2010Service General Hospital, National Defense Medical Center  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-2862-5"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40487-019-00107-y"},{"volume-title":"ACR BI\u2010RADS Atlas: Breast Imaging Reporting and Data System","year":"2013","author":"American College of Radiology","key":"e_1_2_13_4_1"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr027"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07556-9"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520969304"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14799"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2018.03.002"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300891619870247"},{"key":"e_1_2_13_11_1","first-page":"529","article-title":"Carcinoma In\u00a0Situ Involving Sclerosing Adenosis: Seeking the Salient Histological Characteristics to Prevent Overdiagnosis","volume":"47","author":"Cui X.","year":"2017","journal-title":"Annals of Clinical and Laboratory Science"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2012.08.002"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0525"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.9639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T12:21:44Z","timestamp":1748348504000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.9639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/ccr3.9639"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.9639","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e9639"}}