{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:26:09Z","timestamp":1780590369467,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","award":["2024AAC03574"],"award-info":[{"award-number":["2024AAC03574"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760004"],"award-info":[{"award-number":["81760004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Relapsing polychondritis (RP) is a rare immune\u2010mediated systemic inflammatory disease with diverse clinical manifestations. Independent involvement of the respiratory system in RP is uncommon. In the event of respiratory involvement as the initial airway\u2010only manifestation, the diagnosis of RP is challenging and might be delayed, and patients with respiratory involvement exhibit a poor prognosis. However, no specific diagnostic method is currently available for RP with respiratory system involvement as the main clinical manifestation. We present a 49\u2010year\u2010old female with the complaint of chronic dry cough accompanied by shortness of breath after exercise that has persisted for over a year. The patient was treated using corticosteroids. The patient's symptoms improved rapidly with the administration of 5\u2009days of methylprednisolone sodium succinate at a dose of 40\u2009mg\/day. The treatment was then switched to methylprednisolone tablets at a dose of 40\u2009mg\/day, and the dosage was reduced by 4\u2009mg every week until the cessation of therapy. Meanwhile, oral cyclophosphamide tablets were administered once every day at a dose of 100 mg each time. After 1\u2009month of treatment, the symptoms of cough disappeared, the modified british medical research council (mMRC) grade dropped from 4 to 2, and the COPD assessment test (CAT) score dropped from 30 to 17. Repeated CT of the chest revealed that the tracheal wall thickening had alleviated. No recurrence was revealed in the follow\u2010up visit 12\u2009months after drug withdrawal. The patient underwent <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT examination before hormone and immunosuppressive therapy, and <jats:sup>18<\/jats:sup>F\u2010FAPI PET\/CT examination was performed 5\u2009days later. The <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT method revealed slight thickening of the local wall of the trachea and the left and right main bronchus, with no increase in the FDG metabolism, and no abnormalities in the rest of the cartilage. <jats:sup>18<\/jats:sup>F\u2010FAPI PET\u2010CT imaging showed increased FAPI uptake in various parts of the body, including trachea and bronchus. The present study reports that compared to <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT, the <jats:sup>18<\/jats:sup>F\u2010FAPI PET\/CT revealed more lesions and provided a better image contrast, suggesting the latter as a suitable diagnostic method for RP, which could assist in improving the clinical management of RP patients.<\/jats:p>","DOI":"10.1002\/ccr3.9690","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T04:37:02Z","timestamp":1733459822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp><sup>18<\/sup>F<\/scp>\u2010<scp>FAPI<\/scp> versus <scp><sup>18<\/sup>F<\/scp>\u2010<scp>FDG PET<\/scp>\/<scp>CT<\/scp> in the Diagnosis of Relapsing Polychondritis"],"prefix":"10.1002","volume":"12","author":[{"given":"Xiaotong","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine General Hospital of Ningxia Medical 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