{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:15:02Z","timestamp":1788524102340,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T00:00:00Z","timestamp":1758412800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cell Communication and Signaling"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Myopia, a leading global health challenge linked to severe ocular complications, remains poorly understood in terms of molecular mechanisms involving cellular senescence. This study integrates transcriptomic datasets (GSE112155 and GSE151631) from myopia and normal vision samples to unravel senescence\u2010driven pathways and immune interactions underlying myopia pathogenesis. By constructing protein\u2013protein interaction networks and post\u2010transcriptional regulatory axes (mRNA\u2013miRNA\u2013TF), we identified core senescence\u2010associated genes (Tp53, Cdkn1a, and Myc) as central regulators in myopia progression. Single\u2010sample gene set enrichment analysis revealed significant immune dysregulation in myopia, marked by altered infiltration of \u03b3\u03b4 T cells, natural killer T cells, and neutrophils. Functional validation through Tp53 overexpression and Cdkn1a\/Myc knockout in mice demonstrated their critical roles in exacerbating myopia phenotypes, including elongated eye axis and thickened retina. These findings highlight a synergistic interplay between cellular senescence and immune\u2010mediated mechanisms in myopia, supported by multi\u2010omics evidence and in vivo experiments. Our work not only maps the molecular networks bridging senescence and myopia but also proposes novel therapeutic targets for modulating these pathways. This study advances the understanding of myopia as a senescence\u2010associated disorder and underscores the potential of targeting immune\u2013senescence crosstalk for intervention.<\/jats:p>","DOI":"10.1002\/ccs3.70045","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T03:14:41Z","timestamp":1758510881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Integrated genomics reveals cellular senescence\u2010driven molecular networks and immune crosstalk in myopia pathogenesis"],"prefix":"10.1002","volume":"19","author":[{"given":"Wangming","family":"Su","sequence":"first","affiliation":[{"name":"Ophthalmology Department The Second Hospital of Longyan City  Longyan Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinsheng","family":"Qiu","sequence":"additional","affiliation":[{"name":"Ophthalmology Department The Second Hospital of Longyan City  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