{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:38:42Z","timestamp":1793911122142,"version":"4.8.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["20230203582JC"],"award-info":[{"award-number":["20230203582JC"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cell Communication and Signaling"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Abdominal aortic aneurysm (AAA) is a life\u2010threatening vascular disorder lacking effective pharmacological interventions. We identified CD5 molecule\u2010like (CD5L) as a regulator of macrophage polarization in AAA via the phosphoinositide 3\u2010kinase\/protein kinase B\/nuclear factor kappa B (PI3K\/Akt\/NF\u2010\u03baB) pathway. Transcriptomic analyses (GSE47472 and GSE57691) and angiotensin II (AngII)\u2010infused apolipoprotein E\u2010deficient (ApoE\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice showed CD5L upregulation, inversely correlated with M1 macrophage infiltration. In vitro CD5L overexpression reduced, whereas knockdown increased M1 polarization and pro\u2010inflammatory cytokines in RAW264.7 cells and human monocyte\u2010derived macrophages. In vivo, CD5L knockdown aggravated aortic dilation, vascular disruption, and inflammatory mediator expression. Pharmacological modulation confirmed PI3K\/Akt as essential for CD5L's anti\u2010inflammatory action: LY294002 amplified, whereas PI3K activator 740Y\u2010P mitigated CD5L deficiency effects. RNA sequencing confirmed PI3K\/Akt activation downstream of CD5L. These results define CD5L as an immunometabolic checkpoint that suppresses NF\u2010\u03baB\u2010mediated inflammation, suggesting a therapeutic target for AAA.\n                  <\/jats:p>","DOI":"10.1002\/ccs3.70048","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T07:07:39Z","timestamp":1759302459000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Targeting the PI3K\/Akt\/NF\u2010\u03baB axis: Cluster of differentiation 5\u2010like\u2010mediated immunometabolic regulation of macrophage polarization in abdominal aortic aneurysm"],"prefix":"10.1002","volume":"19","author":[{"given":"Hemoren","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery Qian Wei Hospital of Jilin Province  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of 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