{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:49:48Z","timestamp":1782478188560,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cell Communication and Signaling"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sepsis often has a dysregulated inflammatory response and is accompanied by cardiac dysfunction. This study aimed to explore the mechanism of long non\u2010coding RNA MIR503HG (MIR503HG) in regulating sepsis and the inflammatory responses, and sepsis\u2010induced cardiac dysfunction (SICD). 102 sepsis patients were divided into an SICD group (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a031) and a non\u2010SICD group (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a071). A cecal ligation and puncture (CLP) sepsis rat model was constructed. Quantitative reverse transcription polymerase chain reaction (RT\u2010qPCR) was used to evaluate the target gene expression. Enzyme\u2010linked immunosorbent assay was used to measure the levels of myocardial damage markers and inflammatory factors. RNA immunoprecipitation and Dual luciferase assay were used to determine the targeting relationship. Kyoto Encyclopedia of Genes and Genomes analysis was used to predict signaling pathways of target genes. MIR503HG expression was significantly down\u2010regulated in sepsis patients and SICD patients, and it has good diagnostic value for these two types of diseases. Its expression was significantly negatively correlated with myocardial injury markers (cardiac troponin I [cTnI], creatine kinase\u2010MB [CK\u2010MB]), cardiac function indicators (left ventricular ejection fraction), inflammatory factors (interleukin\u20106, tumor necrosis factor\u2010alpha), and disease severity scores (Sequential Organ Failure Assessment, Acute Physiology and Chronic Health Evaluation II). Furthermore, it exerted a protective effect in sepsis: MIR503HG overexpression could effectively alleviate SICD and mitigate the inflammatory response, as evidenced by decreased left ventricular end\u2010diastolic pressure, increased left ventricular systolic pressure, reduced levels of CK\u2010MB and cTnI, as well as restored myocardial systolic\/diastolic capacity (maximal rate of left ventricular pressure rise\/fall [\u00b1dP\/dt]). Mechanistically, MIR503HG functions as a molecular sponge that sequesters microRNA\u2010497\u20105p (miR\u2010497\u20105p), thereby lifting brain\u2010derived neurotrophic factor (BDNF). Delivery of miR\u2010497\u20105p\u2010agomiR partially offset the cardioprotective and anti\u2010inflammatory effects of MIR503HG, whereas overexpression of BDNF partially restored them. MIR503HG relieved sepsis and reduced cardiac dysfunction and inflammatory response by regulating the miR\u2010497\u20105p\/BDNF axis.\n                  <\/jats:p>","DOI":"10.1002\/ccs3.70078","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T16:41:34Z","timestamp":1779813694000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LncRNA MIR503HG serves as a diagnostic biomarker in patients with sepsis and regulates sepsis\u2010induced inflammation and cardiac dysfunction"],"prefix":"10.1002","volume":"20","author":[{"given":"Pingping","family":"Qi","sequence":"first","affiliation":[{"name":"Blood Transfusion Department The Second Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghe","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minsheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengkui","family":"Chen","sequence":"additional","affiliation":[{"name":"Emergency Department Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qile","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The Second Affiliated Hospital of Harbin Medical University  Harbin 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