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This review examines the roles of VDR signaling in inflammatory senescence\u2010associated skin aging. We summarize the actions of VDR through chromatin modification, transcriptional regulation, and coregulator recruitment, which collectively modulate inflammation and cellular senescence in aging skin. Recent findings highlight the protective role of VDR against inflammatory responses and aging processes through multiple pathways, including NF\u2010\u03baB suppression and regulation of senescence\u2010associated pathways. The review discusses cell\u2010type specific VDR regulation in keratinocytes, immune cells, dermal fibroblasts, and stem cells, emphasizing their distinct roles in skin homeostasis. Current therapeutic approaches encompass vitamin D\u2013based treatments, traditional medicine\u2013derived bioactive compounds, and novel drug delivery systems. 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This analysis emphasizes the therapeutic potential of VDR modulation in aging\u2010related skin conditions and highlights priorities for future investigation of VDR\u2010mediated regulation in inflammatory senescence\u2013associated skin diseases.<\/jats:p>","DOI":"10.1002\/ccs3.70088","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:39:34Z","timestamp":1779896374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vitamin D receptor signaling in inflammatory senescence\u2013associated skin aging: Mechanisms and therapeutic potentials"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2516-4100","authenticated-orcid":false,"given":"Liancheng","family":"Guan","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine  Guiyang Guizhou 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