{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:55:28Z","timestamp":1790618128901,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2025J01831"],"award-info":[{"award-number":["2025J01831"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cell Communication and Signaling"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pregnancy\u2010induced hypertension (PIH) severely impairs placental function, yet its microenvironmental alterations and potential interventions remain unclear. Here, we combined single\u2010cell RNA sequencing (scRNA\u2010seq) with an in vivo model to investigate the protective effects of\n                    <jats:italic>Prevotella loescheii<\/jats:italic>\n                    (PL) in PIH. scRNA\u2010seq revealed that PIH reshaped placental cellular composition, reducing trophoblasts and myeloid cells while increasing smooth muscle cells, and disrupted cell\u2013cell communication. Functional analyses identified oxidative stress (OS) and macrophage\u2010driven pyroptosis via the NLRP3 inflammasome as key pathological features. Trajectory analysis further demonstrated the depletion of Hofbauer cells, which was restored by PL. In vivo, PL significantly alleviated PIH phenotypes, including proteinuria and placental structural damage. Mechanistically, PL reduced proinflammatory cytokines, suppressed mitochondrial OS and pyroptosis, and partially restored short\u2010chain fatty acid metabolism. Collectively, these findings indicate that PL ameliorates PIH by modulating the placental immune microenvironment and metabolic homeostasis, providing a potential therapeutic strategy.\n                  <\/jats:p>","DOI":"10.1002\/ccs3.70099","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:33Z","timestamp":1787028633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Prevotella loescheii<\/i>\n                    attenuates pregnancy\u2010induced hypertension by reshaping placental immunity and halting macrophage pyroptosis"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1560-6411","authenticated-orcid":false,"given":"Jingjing","family":"Wu","sequence":"first","affiliation":[{"name":"Obstetrics Department The Second Affiliated Hospital Fujian Medical University  Fujian Quanzhou 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010med\u2010050423\u2010085626"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2203388"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.120.018494"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201043780\u2010w"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.05.014"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010021\u201002201\u20104"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.08.075"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14030624"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1071029"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.15279"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15071682"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.06.034"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.122.320771"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27248801"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104347"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010020\u201000630\u20103"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010019\u20100228\u20102"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010021\u201000154\u2010z"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011\u2010019\u201001246\u20108"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/hjh.0000000000002981"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205019"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs20191253"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.878924"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101706"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0282685"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.70289"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109523"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1386528"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010023\u201001136\u2010x"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010022\u201002260\u20101"}],"container-title":["Journal 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