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In this work, transaminases were directly reacted with hydrazones in a novel approach to form amine products. Several substrates were investigated, including those with furan and phenyl moieties. It was determined that the amine yields increased when an additional electrophile was added to the reaction mixture, suggesting that they can sequester the hydrazine released in the reaction. Pyridoxal 5\u2019\u2010phosphate (PLP), a cofactor for transaminases, and polyethylene glycol (PEG)\u2010aldehydes were both found to increase the yield of amine formed. Notably, the amination of (<jats:italic>S<\/jats:italic>)\u2010(\u2212)\u20101\u2010amino\u20102\u2010(methoxymethyl)pyrrolidine (SAMP) hydrazones gave promising results as a method to form chiral \u03b2\u2010substituted amines in good yield.<\/jats:p>","DOI":"10.1002\/cctc.202101008","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T11:36:28Z","timestamp":1630496188000},"page":"4520-4523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Direct Conversion of Hydrazones to Amines using Transaminases"],"prefix":"10.1002","volume":"13","author":[{"given":"Eve M.","family":"Carter","sequence":"first","affiliation":[{"name":"Department of Chemistry University College London  20 Gordon Street London WC1H 0AJ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Subrizi","sequence":"additional","affiliation":[{"name":"Department of Chemistry University 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