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Functional genes in these loci are cell\u2010type specific. The aim of this study was to elucidate potentially functional genes associated with BP in the aorta through the utilization of RNA modification\u2010associated single\u2010nucleotide polymorphisms\u00a0(RNAm\u2010SNPs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Utilizing large\u2010scale genetic data of 757,601 individuals from the UK Biobank and International Consortium of Blood Pressure\u00a0consortium, we identified associations between RNAm\u2010SNPs and BP. The association between RNAm\u2010SNPs, gene expression, and BP were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 355 RNAm\u2010SNPs related to m<jats:sup>6<\/jats:sup>A, m<jats:sup>1<\/jats:sup>A, m<jats:sup>5<\/jats:sup>C, m<jats:sup>7<\/jats:sup>G, and A\u2010to\u2010I modification were associated with BP. The related genes were enriched in the pancreatic secretion pathway and renin secretion pathway. The BP GWAS signals were significantly enriched with m<jats:sup>6<\/jats:sup>A\u2010SNPs, highlighting the potential functional relevance of m<jats:sup>6<\/jats:sup>A in physiological processes influencing BP. Notably, m<jats:sup>6<\/jats:sup>A\u2010SNPs in <jats:italic>CYP11B1, PDE3B, HDAC7, ACE, SLC4A7, PDE1A, FRK, MTHFR, NPPA, CACNA1D<\/jats:italic>, and <jats:italic>HDAC9<\/jats:italic> were identified. Differential methylation and differential expression of the BP genes in FTO\u2010overexpression and METTL14\u2010knockdown vascular smooth muscle cells were detected. RNAm\u2010SNPs were associated with ascending and descending aorta diameter and the genes showed differential methylation between aortic dissection (AD) cases and controls. In scRNA\u2010seq study, we identified <jats:italic>ARID5A, HLA\u2010DPB1, HLA\u2010DRA, IRF1, LINC01091, MCL1, MLF1, MLXIPL, NAA16, NADK, RERG, SRM<\/jats:italic>, and <jats:italic>USP53<\/jats:italic> as differential expression genes for AD in aortic cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study identified RNAm\u2010SNPs in BP loci and elucidated the associations between the RNAm\u2010SNPs, gene expression, and BP. The identified BP\u2010associated genes in aortic cells were associated with AD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cdt3.124","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T12:25:29Z","timestamp":1714479929000},"page":"118-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unveiling blood pressure\u2010associated genes in aortic cells through integrative analysis of GWAS and RNA modification\u2010associated variants"],"prefix":"10.1002","volume":"10","author":[{"given":"Huan","family":"Zhang","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Department of Epidemiology, School of Public Health Medical College of Soochow University Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxi","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangsu 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