{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:08:47Z","timestamp":1790633327246,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:00:00Z","timestamp":1715472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chronic Diseases and Translational Medicine"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Growth differentiation factor\u201015 (GDF\u201015) is a stress response protein and is related to cardiovascular diseases (CVD). This study aimed to investigate the association between GDF\u201015 and pre\u2010eclampsia (PE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The study involved 299 pregnant women, out of which 236 had normal pregnancies, while 63 participants had PE. Maternal serum levels of GDF\u201015 were measured by using enzyme\u2010linked immunosorbent assay kits and then translated into multiple of median (MOM) to avoid the influence of gestational week at blood sampling. Logistic models were performed to estimate the association between GDF\u201015 MOM and PE, presenting as odd ratios (ORs) and 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MOM of GDF\u201015 in PE participants was higher compared with controls (1.588\u2009vs. 1.000, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In the logistic model, pregnant women with higher MOM of GDF\u201015 (&gt;1) had a 4.74\u2010fold (95% CI\u2009=\u20092.23\u201310.08, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) increased risk of PE, adjusted by age, preconceptional body mass index, gravidity, and parity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results demonstrated that higher levels of serum GDF\u201015 were associated with PE. GDF\u201015 may serve as a biomarker for diagnosing PE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cdt3.126","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T04:59:39Z","timestamp":1715576379000},"page":"140-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between plasma growth differentiation factor 15 levels and pre\u2010eclampsia in China"],"prefix":"10.1002","volume":"10","author":[{"given":"Shuhong","family":"Xu","sequence":"first","affiliation":[{"name":"Taicang Affiliated Hospital of Soochow University, The First People's Hospital of TaiCang Soochow University Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7404-7733","authenticated-orcid":false,"given":"Yicheng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistic, Jiangsu Key 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