{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:16:56Z","timestamp":1782494216502,"version":"3.54.5"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chronic Diseases and Translational Medicine"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The rising incidence and death rates linked to Alzheimer's disease (AD) highlight an urgent issue. Genetic screening is celebrated as a significant advancement for its early detection capabilities, pinpointing those at risk before the emergence of symptoms. Yet, the limited availability of these technologies highlights a critical gap in widespread application. This review pivots to the potential of presymptomatic clinical assessments as a readily available, economical, and simple strategy for early detection. Traditionally, AD diagnosis relies on the late\u2010stage identification of cognitive deterioration, functional impairments, and neuropsychiatric symptoms, coinciding with advanced brain degeneration. Conversely, emerging research identifies early indicators preceding significant degeneration, manifesting years before clinical symptoms. We introduce a mnemonic, MEMORIES, to categorize these prodromal: Metabolism changes, Eye\/visual impairments, March (refer to gait disturbances), Olfactory dysfunction, Rhythm (blood pressure and heart rate), Insensitivity of the tongue, Ears (hearing loss), and Stool alterations. Recognizing these prodromal through clinical examinations provides a valuable strategy for initiating preventative actions against brain degeneration. This approach advocates for broadening the screening lens beyond genetic screening to encompass clinical evaluations, enhancing early detection and intervention opportunities for AD.<\/jats:p>","DOI":"10.1002\/cdt3.150","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T09:43:39Z","timestamp":1725356619000},"page":"22-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early detection of Alzheimer's disease using the MEMORIES mnemonic"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0927-4919","authenticated-orcid":false,"given":"Valentinus","family":"Besin","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Surabaya Surabaya Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0487-6926","authenticated-orcid":false,"given":"Farizky M.","family":"Humardani","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Surabaya Surabaya Indonesia"},{"name":"Doctoral Study Program in Medical Science, Faculty of Medicine Universitas Brawijaya Malang Indonesia"},{"name":"Bioinformatics Research Center, Indonesian Bioinformatics and Biomolecular Malang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.2161"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(21)00140-9"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-018-0090-9"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.09.069"},{"key":"e_1_2_13_6_1","doi-asserted-by":"crossref","unstructured":"SeathP Macedo\u2010OrregoLE VelayudhanL. Clinical characteristics of early\u2010onset versus late\u2010onset Alzheimer's disease: a systematic review and meta\u2010analysis.Int Psychogeriatr. Published online2023.doi:10.1017\/S1041610223000509","DOI":"10.1017\/S1041610223000509"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12839"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2023.104648"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00687-2"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02289-4"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0872-14.2014"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2015.11.011"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjdh\/ztad022"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867420976853"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-52406-8"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-30167-0"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.08.073"},{"key":"e_1_2_13_18_1","first-page":"919","article-title":"Epidemiology and management of chronic constipation in elderly patients","volume":"10","author":"Vazquez Roque M","year":"2015","journal-title":"Clin Interv Aging"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13940"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000527513"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-023-02696-5"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-023-03854-w"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00423.2011"},{"key":"e_1_2_13_24_1","doi-asserted-by":"crossref","unstructured":"KangJ LeeM ParkM et al. Slow gut transit increases the risk of Alzheimer's disease: an integrated study of the bi\u2010national cohort in South Korea and Japan and Alzheimer's disease model mice.J Adv Res. Published online2023.doi:10.1016\/j.jare.2023.12.010","DOI":"10.1016\/j.jare.2023.12.010"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-021-00401-6"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.21636"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988720901779"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12298"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.110816"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80768-2"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx054"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2020.07.009"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104862"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2021.01.005"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.02.047"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2016.07.032"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2015.08.008"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-020-01691-7"},{"issue":"3","key":"e_1_2_13_39_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0248673","article-title":"Comparison between the timing of the occurrence of taste sensitivity changes and short\u2010term memory decline due to aging in SAMP1 mice","volume":"16","author":"Narukawa M","year":"2021","journal-title":"PLoS One"},{"key":"e_1_2_13_40_1","doi-asserted-by":"crossref","unstructured":"MantovaniE ZaniniA CecchiniMP TamburinS. The association between neurocognitive disorders and gustatory dysfunction: a systematic review and meta\u2010analysis.Neuropsychol Rev. Published online February2023.doi:10.1007\/s11065-023-09578-3","DOI":"10.1007\/s11065-023-09578-3"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610215001337"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-05201-2"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-023-08019-4"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200376"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.08.077"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2020.12.029"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa036"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101361"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105344"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0199-3"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2018.03.004"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92802-y"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134705"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12370"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100899"}],"container-title":["Chronic Diseases and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cdt3.150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T17:21:15Z","timestamp":1744392075000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cdt3.150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,3]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/cdt3.150"],"URL":"https:\/\/doi.org\/10.1002\/cdt3.150","archive":["Portico"],"relation":{},"ISSN":["2589-0514","2589-0514"],"issn-type":[{"value":"2589-0514","type":"print"},{"value":"2589-0514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,3]]},"assertion":[{"value":"2024-06-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}