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The pathogenesis of myeloma bone disease (MBD) involves disruption of bone reconstitution balance including excessive activation of osteoclasts, inhibition of osteoblasts, and participation of osteocytes and bone marrow stromal cells. Various factors, such as the receptor activator of nuclear factor\u2010\u03baB ligand (RANKL)\/osteoprotegerin (OPG), dickkopf\u20101 (DKK\u20101), sclerostin, and activin\u2010A, are involved in the development of MBD. Bisphosphonates and the anti\u2010RANKL antibody denosumab are currently the main treatment options for MBD, delaying the onset of SREs. Denosumab is preferred in patients with MM and renal dysfunction. Although effective drugs have been approved, antimyeloma therapy is the most important method for controlling bone disease.<\/jats:p>","DOI":"10.1002\/cdt3.35","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T17:13:07Z","timestamp":1656954787000},"page":"264-270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pathophysiology and therapeutic advances in myeloma bone disease"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-7905","authenticated-orcid":false,"given":"Fujing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Beijing China"},{"name":"Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing 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