{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T18:38:11Z","timestamp":1784659091190,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chronic Diseases and Translational Medicine"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The differential diagnosis of mucoepidermoid carcinoma (MEC) from neoplasm undergoing mucinous features brings more pitfalls to pathologists. Combining specific <jats:italic>MAML2<\/jats:italic> gene rearrangement and histological characteristics may be the solution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five tumors with mucinous components were selected for differential diagnosis of MEC. All the cases were detected for <jats:italic>MAML2<\/jats:italic> gene rearrangement. The cases diagnosed as MEC were classified into four variants: classic, oncocytic, Warthin\u2010like, and nonclassified, and they were graded using the Brandwein system. The histological characteristics of non\u2010MECs were summarized for differential diagnosis. Univariate survival analysis was performed on MECs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 16 MECs; 62.5% were <jats:italic>MAML2<\/jats:italic> rearranged. For the low\u2010, intermediate\u2010, and high\u2010grade MECs, the rate of rearrangement was 83.3%, 100%, and 28.6%, respectively. Both the oncocytic and Warthin\u2010like MECs were <jats:italic>MAML2<\/jats:italic> rearranged. For the classic and nonclassified MECs without <jats:italic>MAML2<\/jats:italic> rearrangement, non\u2010keratinized squamoid cells and distinctive mucinous cells were essential diagnostic criteria. On survival analysis, all the disease progression occurred in high\u2010grade MECs (<jats:italic>p<\/jats:italic>\u2009=\u20090.038). Nine cases were diagnosed as non\u2010MECs: pleomorphic adenoma with mucinous metaplasia showed no ex\u2010capsular involvement; metaplastic Warthin tumor appeared with overt keratinization and residual oncocytic bilayered epithelium; mix squamous cell and glandular papilloma showed an endobronchial papillary growing pattern; adenosquamous carcinoma was accompanied by squamous carcinoma in situ of the overlying mucosa. All the non\u2010MECs were negative for <jats:italic>MAML2<\/jats:italic> rearrangement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The application of combining <jats:italic>MAML2<\/jats:italic> rearrangement and histological characteristics is helpful in the differential diagnosis between MEC and other tumors with mucinous components.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cdt3.55","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T04:22:46Z","timestamp":1672719766000},"page":"29-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinicopathological practice in the differential diagnosis of mucoepidermoid carcinoma from neoplasms with mucinous component"],"prefix":"10.1002","volume":"9","author":[{"given":"Yuelu","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Pathology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Cancer Center, National Clinical Research Center for Cancer, 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