{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T13:10:08Z","timestamp":1749215408648,"version":"3.41.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chronic Diseases and Translational Medicine"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The increasing incidence of inflammatory bowel disease (IBD) presents significant medical and societal challenges. A well\u2010designed IBD database is crucial for both epidemiological studies and clinical management. However, inconsistencies between regional databases hinder cross\u2010institutional and international research, especially between Eastern and Western societies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We developed a new IBD database, the 301 IBD database, integrating the IBD clinical characteristics from the Penn IBD database (USA) and the latest IBD guidelines and consensus and clinical practices of the Chinese PLA General Hospital (PLAGH). We applied this database to analyze clinical data of IBD inpatients at PLAGH from 2008 to 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 301 IBD database contains 490 items in 6 sections including demographic characteristics, personal history, clinical phenotype, disease activity, laboratory tests and examinations, and treatment. Features of the 301 IBD database include inpatient focus, biochemical indicators and opportunistic infection focus, and more about ulcerative colitis (UC)\u2010associated complications. Single\u2010center analysis revealed an increasing hospitalization trend, from 2.35% in 2008 to 3.94% in 2023. We found that the clinical characteristics of our UC inpatients are predominantly male (62.5%), extensive lesions (55.1%), low usage of biologics (4.1%), and a high incidence of UC\u2010CRC (3.0%). The clinical characteristics of CD inpatients included male predominance (68.39%), early onset age (35.43\u2009\u00b1\u200914.75\u2010year\u2010old), and high rate of surgery (25.81%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The 301 IBD database, integrating Eastern and Western clinical data, provides a valuable tool for IBD clinical research. Future international, multicenter collaborations are expected to further enhance its utility.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cdt3.70000","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T10:04:51Z","timestamp":1739527491000},"page":"130-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and Initial Use of a New Inflammatory Bowel Disease Clinical Database Integrating Both Eastern and Western Clinical Characteristics"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3454-5636","authenticated-orcid":false,"given":"Jingshuang","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Medical Center, Chinese PLA General Hospital Beijing China"},{"name":"School of Medicine Nankai University Tianjin China"},{"name":"Department of Gastroenterology Fuwai Hospital Chinese 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