{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T06:43:33Z","timestamp":1748587413928,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T00:00:00Z","timestamp":1694304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chronic Diseases and Translational Medicine"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>COVID\u201019 limitations have hindered the implementation of new technologies by preventing proctors from coming to the site. We share our first experience of magnetic resonance imaging (MRI)\u2010guided focused ultrasound (MRgFUS) treatment with an international remote online proctorship, and develop and evaluate the methodology of remote MRgFUS proctorship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010center, nonrandomized controlled prospective study included 94 patients: 27 with essential tremor (ET) and 67 with tremor\u2010dominant Parkinson's disease (PD). The coming of proctors was impossible, so we arranged for the remote participation of proctors from the United Kingdom, Spain, and Israel. A total of 38 patients (40.4%) received telemedicine\u2010proctored treatment (proctor group) and 56 received their treatment independently (solo group). We used the Clinical Rating Scale for Tremor (CRST) for ET patients and the Unified Parkinson's Disease Rating Scale (UPDRS) Part III for PD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients with ET, success rates were 81.8% (proctor group) and 100% (solo group) (<jats:italic>p<\/jats:italic>\u2009=\u20090.22). CRST reduction on the treated side was 71.43% [65.83%; 80.56%] (proctor group) versus 60.87% [53.99; 79.58] (solo group) (<jats:italic>p<\/jats:italic>\u2009=\u20090.19). None of the patients showed worsening of tremors within 1 year. In patients with PD, the success rates were 92.6% (proctor group) and 100% (solo group) (<jats:italic>p<\/jats:italic>\u2009=\u20090.08). The UPDRS Part III improvement was 30.1% (proctor group) versus 39.9% (solo group) (<jats:italic>p<\/jats:italic>\u2009=\u20090.003). The 1\u2010year recurrence rate was 40% (proctor group) and 17.5% (solo group) (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). No complications were observed at 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We developed a feasible and safe methodology for telemedicine remote online\u2010proctored MRgFUS treatment. No significant difference was observed between the solo and developed remote proctor protocols in terms of complication rate, effect, and long\u2010term results; however, UPDRS Part III improvement was better in the PD solo group. This study demonstrated that the MRgFUS international proctorship can be performed successfully remotely.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cdt3.92","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T05:49:54Z","timestamp":1694411394000},"page":"40-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Magnetic resonance imaging\u2010guided focused ultrasound thalamotomy launch with remote telemedicine international proctorship"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0511-9345","authenticated-orcid":false,"given":"Igor V.","family":"Buzaev","sequence":"first","affiliation":[{"name":"Department of Surgery Bashkir State Medical University Ufa Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rezida M.","family":"Galimova","sequence":"additional","affiliation":[{"name":"Department of Surgery Bashkir State Medical University Ufa Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinara I.","family":"Nabiullina","sequence":"additional","affiliation":[{"name":"Intelligent Neurosurgery Clinic, Ltd. International Medical Center V.S. Buzaev memorial Ufa Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey N.","family":"Illarioshkin","sequence":"additional","affiliation":[{"name":"Directorate, Research Center of Neurology Volokolamskoye Shosse Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naufal Sh.","family":"Zagidullin","sequence":"additional","affiliation":[{"name":"Department of Surgery Bashkir State Medical University Ufa Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shamil M.","family":"Safin","sequence":"additional","affiliation":[{"name":"Department of Surgery Bashkir State Medical University Ufa Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462321000155"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002948"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7524925"},{"key":"e_1_2_10_5_1","first-page":"9","article-title":"Terapiya dvigatel'ny'x narushenij metodom fokusirovannogo ul'trazvuka pod kontrolem magnitno\u2010rezonansnoj tomografii. Rekomendacii dlya vrachej\u2010nevrologov po otboru pacientov [Therapy of motor disorders by the method of focused ultrasound under the control of magnetic resonance imaging. recommendations for neurologists on selection of patients]","volume":"1","author":"Galimova RM","year":"2020","journal-title":"Byul Nac ob\u2010va po izuch bolezni Parkinsona i rasstrojstv dvizheniya"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21801"},{"key":"e_1_2_10_7_1","unstructured":"FDA. FDA approves first MRI\u2010guided focused ultrasound device to treat essential tremor.2016. Accessed February 13 2022.https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-mri-guided-focused-ultrasound-device-treat-essential-tremor"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.10.JNS16758"},{"key":"e_1_2_10_9_1","unstructured":"Registracionnoe udostoverenie na medicinskoe izdelie ot 13.02.2017 No RZN 2017\/5378 F.S.P.N.V.S.Z. (ROSZDRAVNADZOR) Editor.2017."},{"key":"e_1_2_10_10_1","first-page":"225","volume-title":"Clinical Rating Scale for Tremor","author":"Fahn S","year":"1988"},{"key":"e_1_2_10_11_1","first-page":"271","volume-title":"Parkinson's Disease and Movement Disorders","author":"Fahn S","year":"1993"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10473"},{"issue":"3","key":"e_1_2_10_13_1","first-page":"2","article-title":"Consensus statement of the Movement Disorder Society on Tremor","volume":"13","author":"Deuschl G","year":"1998","journal-title":"Mov Disorders"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3171\/2020.6.JNS192773"},{"key":"e_1_2_10_15_1","unstructured":"INSIGHTEC. Insightec for neurosurgery. Insightec. 2017. Accessed January 25 2020.http:\/\/www.insightec.com\/clinical\/neurosurgery"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-325278"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13210"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.601153"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.oa.2020-0370"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002319"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25126"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3171\/2019.12.JNS192219"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3171\/2020.6.JNS192773"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-212810"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000465"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/2050-5736-2-11"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.3098"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30403-9"}],"container-title":["Chronic Diseases and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cdt3.92","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T16:21:00Z","timestamp":1709655660000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cdt3.92"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,10]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/cdt3.92"],"URL":"https:\/\/doi.org\/10.1002\/cdt3.92","archive":["Portico"],"relation":{},"ISSN":["2589-0514","2589-0514"],"issn-type":[{"type":"print","value":"2589-0514"},{"type":"electronic","value":"2589-0514"}],"subject":[],"published":{"date-parts":[[2023,9,10]]},"assertion":[{"value":"2023-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}