{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:53:15Z","timestamp":1791604395257,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K09325"],"award-info":[{"award-number":["23K09325"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Non\u2010syndromic cleft lip with or without palate (NSCL\/P) ranks among the most prevalent congenital craniofacial anomalies globally. In Japan, reported rates of cleft lip and\/or palate range from 1 in 500 to 1 in 700 live births. This study aims to explore potential sex\u2010specific interactions of\n                    <jats:italic>NOG<\/jats:italic>\n                    rs227731 across NSCL\/P subtypes in a Japanese population. This case\u2013control study included 420 participants recruited from the Cleft Lip and Palate Centre at Aichi Gakuin Dental Hospital in Nagoya, Japan. The study population was divided into three groups: 110 individuals with non\u2010syndromic cleft lip and palate (NSCLP), 110 with non\u2010syndromic cleft lip only (NSCLO), and a control group of 200 unaffected individuals. A balanced 1:1 male\u2010to\u2010female ratio was maintained within each group to enhance the statistical power of sex\u2010stratified analyses. There was no evidence about the association of rs227731 with NSCL\/P and the NSCLP group in both gender clusters. In the NSCLO subgroup, a significant difference emerged in the allelic model among males (OR\u2009=\u20091.66, 95% CI: 1.03\u20132.69,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0385). Conversely, no significant associations were detected in females across any of the models. In conclusion, this study's findings suggest a possible association between the NOG rs227731 variant in males of NSCLO as an increasing risk factor.\n                  <\/jats:p>","DOI":"10.1002\/cga.70036","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:40:43Z","timestamp":1767775243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Suggestive Association Between the\n                    <i>NOG<\/i>\n                    rs227731 Polymorphism and Non\u2010Syndromic Cleft Lip With or Without Palate Subtypes in a Japanese Cohort"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7872-9291","authenticated-orcid":false,"given":"Le Kha","family":"Anh","sequence":"first","affiliation":[{"name":"Division of Research and Treatment for Oral Maxillofacial Congenital Anomalies Aichi Gakuin University  Nagoya Japan"},{"name":"School of Dentistry Hanoi Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9027-5322","authenticated-orcid":false,"given":"Tran Phuong","family":"Thao","sequence":"additional","affiliation":[{"name":"Division of Research and Treatment for Oral Maxillofacial Congenital Anomalies Aichi Gakuin University  Nagoya Japan"},{"name":"School of Dentistry Hanoi Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruyuki","family":"Niimi","sequence":"additional","affiliation":[{"name":"Division of Research and Treatment for Oral Maxillofacial Congenital Anomalies Aichi Gakuin University  Nagoya Japan"},{"name":"Cleft Lip and Plate Center Aichi Gakuin University Dental Hospital  Nagoya Japan"},{"name":"Division of Speech, Hearing, and Language Aichi Gakuin University Dental Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Research and Treatment for Oral Maxillofacial Congenital Anomalies Aichi Gakuin University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toko","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Cleft Lip and Plate Center Aichi Gakuin University Dental Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Division of Research and Treatment for Oral Maxillofacial Congenital Anomalies Aichi Gakuin University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisato","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Division of Research and Treatment for Oral Maxillofacial Congenital Anomalies Aichi Gakuin University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Imura","sequence":"additional","affiliation":[{"name":"Division of Research and Treatment for Oral Maxillofacial Congenital Anomalies Aichi Gakuin University  Nagoya Japan"},{"name":"Cleft Lip and Plate Center Aichi Gakuin University Dental Hospital  Nagoya Japan"},{"name":"Division of Speech, Hearing, and Language Aichi Gakuin University Dental Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisataka","family":"Kondo","sequence":"additional","affiliation":[{"name":"Junior College Aichi Gakuin University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Huu","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia \u2010 Resuscitation Hanoi Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong Minh","family":"Son","sequence":"additional","affiliation":[{"name":"School of Dentistry Hanoi Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vo Truong Nhu","family":"Ngoc","sequence":"additional","affiliation":[{"name":"School of Dentistry Hanoi Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4637-7108","authenticated-orcid":false,"given":"Pham Nguyen Gia","family":"Loc","sequence":"additional","affiliation":[{"name":"Division of Research and Treatment for Oral Maxillofacial Congenital Anomalies Aichi Gakuin University  Nagoya Japan"},{"name":"Oral Maxillofacial Surgery Department Odonto \u2010Maxillo Facial Hospital of Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroo","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Division of Speech, Hearing, and Language Aichi Gakuin University Dental Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagana","family":"Natsume","sequence":"additional","affiliation":[{"name":"Division of Research and Treatment for Oral Maxillofacial Congenital Anomalies Aichi Gakuin University  Nagoya Japan"},{"name":"Cleft Lip and Plate Center Aichi Gakuin University Dental Hospital  Nagoya Japan"},{"name":"Division of Speech, Hearing, and Language Aichi Gakuin University Dental Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7943-2284","authenticated-orcid":false,"given":"Nagato","family":"Natsume","sequence":"additional","affiliation":[{"name":"Division of Research and Treatment for Oral Maxillofacial Congenital Anomalies Aichi Gakuin University  Nagoya Japan"},{"name":"Cleft Lip and Plate Center Aichi Gakuin University Dental Hospital  Nagoya Japan"},{"name":"Division of Speech, Hearing, and Language Aichi Gakuin 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