{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:52:02Z","timestamp":1791604322958,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The Burden of urogenital congenital anomalies (UCAs) among children and adolescence aged under 24\u2009years in the world has not been comprehensively studied regarding the Global Burden of Disease Study (GBD) database 2021. This study aims to characterize the burden of UCAs in this population from 1990 through 2021. We extracted data from GBD 2021 to collect information on the prevalence, deaths, and disability\u2010adjusted life years (DALYs) linked to UCAs from 1990 to 2021. Furthermore, we calculated the estimated annual percentage change (EAPC) for each metric to assess temporal trends. In 2021, there were 6343.41 thousand prevalent cases of UCAs worldwide, with UCAs accounting for 7.50 thousand deaths and 882.19 thousand DALYs. UCAs prevalence increased by 3.97% between 1990 and 2021, with the global age\u2010standardized rate (ASR) of prevalence increasing to 89.76 per 100\u2009000. Global deaths decreased by 23.48% over the same interval, with an ASR of 0.12 cases per 100\u2009000. The worldwide DALYs burden decreased by 1.40%, corresponding to an ASR of 13.56 DALYs per 100\u2009000 population. The prevalence of UCAs in the 0\u20139 age group has been increasing annually, reaching a peak in the 5\u20139\u2009years age range. Over the past 32\u2009years, mortality and DALYs attributable to UCAs have steadily declined, despite persistent regional disparities. These findings offer vital guidance for developing targeted prevention and management strategies for UCAs.<\/jats:p>","DOI":"10.1002\/cga.70039","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T07:45:04Z","timestamp":1768203904000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Worldwide Burden of Urogenital Congenital Anomalies Across Childhood and Adolescence, 1990\u20132021: Results From the Global Burden of Disease Study 2021"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7294-0985","authenticated-orcid":false,"given":"Jie","family":"Luo","sequence":"first","affiliation":[{"name":"Good Clinical Practice Center Guizhou Provincial People's Hospital  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0579-348X","authenticated-orcid":false,"given":"Xi","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery The Affiliated Hospital of Guizhou Medical University  Guiyang China"},{"name":"School of Clinical Medicine Guizhou Medical University  Guiyang China"},{"name":"Faculty of Medical and Health Sciences University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,11]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102873"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12581019"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00906"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-017-2864-5"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.14661119"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfae115"},{"key":"e_1_2_14_8_1","first-page":"1720","article-title":"Investigating the Appropriateness of Admission and Hospitalization at a Teaching Hospital: A Case of a Developing Country","volume":"46","author":"Nekoei Moghadam M.","year":"2017","journal-title":"Iranian Journal of Public 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