{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:53:30Z","timestamp":1791604410273,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K10241"],"award-info":[{"award-number":["22K10241"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K20074"],"award-info":[{"award-number":["24K20074"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cleidocranial dysplasia is a congenital malformation syndrome characterized by skeletal and dental abnormalities as well as distinctive craniofacial features. Most previous reports have relied on two\u2010dimensional radiographs, and no comprehensive three\u2010dimensional investigations have been conducted. This study aimed to provide a detailed overview of craniofacial features in patients with cleidocranial dysplasia using computed tomography. Craniofacial characteristics of 11 Japanese patients were assessed using three\u2010dimensional computed tomography reconstructions. Qualitative evaluations were performed across three regions: cranial, nasomaxillary complex, and mandibular. In the cranial region, all patients presented Wormian bones and hypoplastic mastoid processes. In the nasomaxillary complex, hypoplastic nasal bones, atypical piriform aperture contours, and discontinuous or downward\u2010bent zygomatic arches were frequently observed. In the mandibular region, atypical sigmoid notch morphology, nearly parallel\u2010sided ascending rami, and abnormally rounded mandibular angles were identified. Novel findings included aplastic\/hypoplastic styloid processes, thin\u2010appearing orbital walls, downward displacement of the temporal process of the maxillary bone, and atypical coronoid process morphology. Bilateral expression of all craniofacial traits was also newly confirmed. To our knowledge, this is the first comprehensive three\u2010dimensional study of craniofacial morphology in cleidocranial dysplasia. These observations provide new insights into the pathophysiology and developmental mechanisms underlying craniofacial anomalies in affected patients.<\/jats:p>","DOI":"10.1002\/cga.70044","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T05:22:37Z","timestamp":1770355357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Computed Tomography Analysis of Craniofacial Features in Japanese Patients With Cleidocranial Dysplasia"],"prefix":"10.1002","volume":"66","author":[{"given":"Chia\u2010Yu","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Maxillofacial Orthognathics, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9005-7972","authenticated-orcid":false,"given":"Hidekazu","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Orthognathics, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1232-514X","authenticated-orcid":false,"given":"Michiko","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Orthognathics, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Moriyama","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Orthognathics, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr\/63490079"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.36.3.177"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320420307"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/342717"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2017.07.002"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109416(81)90465\u20106"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj\/dmfr\/4600417"},{"issue":"2","key":"e_1_2_12_9_1","first-page":"98","article-title":"Craniofacial Abnormalities in 52 School\u2010Age and Adult Patients With Cleidocranial Dysplasia","volume":"13","author":"Jensen B. 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