{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:51:29Z","timestamp":1791604289716,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":85,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Congenital Anomalies"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Omphalocele, Cloacal Exstrophy, Imperforate Anus, Spinal Defects (OEIS) complex is an extremely rare congenital disorder, and data on long\u2010term functional and developmental outcomes remain scarce. We aimed to evaluate ambulatory, urological, and intellectual outcomes in a cohort of patients with OEIS complex. We retrospectively reviewed 10 patients with OEIS complex born at our institution between 1991 and 2021. Spinal defects were classified radiologically or intraoperatively. Ambulatory and urinary outcomes were assessed at the most recent follow\u2010up, and intellectual status was evaluated in patients who were aged \u2265\u20096\u2009years. At a mean follow\u2010up of 114\u2009months (range, 4\u2013348), five patients were independently ambulatory, two were ambulatory with orthoses, and two were nonambulatory. Two patients achieved dry time with clean intermittent catheterization, while seven remained incontinent. Among seven school\u2010aged patients, five attended regular schools, one required special education, and one could not attend due to complications. Spinal anomalies included spinal lipomas (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096) and terminal myelocystoceles (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20094). In this cohort, long\u2010term ambulatory and intellectual outcomes were generally favorable in the absence of severe complications, whereas urinary continence remained challenging. Given the rarity of OEIS complex, additional multi\u2010institutional and multidisciplinary studies with extended follow\u2010up are needed.\n                  <\/jats:p>","DOI":"10.1002\/cga.70054","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:28:51Z","timestamp":1774621731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Focused Clinical Observation of Functional Outcomes in Children With\n                    <scp>OEIS<\/scp>\n                    Complex"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0614-2314","authenticated-orcid":false,"given":"Osamu","family":"Yazawa","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Kanagawa Children's Medical Center  Kanagawa Japan"},{"name":"Department of Neurosurgery Graduate School of Medicine, Yokohama City University  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Hirokawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kanagawa Children's Medical Center  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Graduate School of Medicine, Yokohama City University  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryutaro","family":"Fukuyama","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Graduate School of Medicine, Yokohama City University  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokuni","family":"Honma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Graduate School of Medicine, Yokohama City University  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kanagawa Children's Medical Center  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Graduate School of Medicine, Yokohama City University  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2009.09.011"},{"key":"e_1_2_11_3_1","first-page":"253","article-title":"The OEIS Complex (Ompahalocele, Exstrophy, Imperforate Anus, Spinal Defects)","volume":"14","author":"Carey J. C.","year":"1978","journal-title":"Birth Defects Original Article Series"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2021.1.PEDS20648"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67162-3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-007-0519-y"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.10.PEDS16247"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000028905"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2023.09.013"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.49.487"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/jpn.JPN_131_19"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2012.04.017"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320530105"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33757"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37666"}],"container-title":["Congenital Anomalies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cga.70054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cga.70054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cga.70054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:59:18Z","timestamp":1791601158000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cga.70054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/cga.70054"],"URL":"https:\/\/doi.org\/10.1002\/cga.70054","archive":["Portico"],"relation":{},"ISSN":["0914-3505","1741-4520"],"issn-type":[{"value":"0914-3505","type":"print"},{"value":"1741-4520","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70054"}}