{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:58:58Z","timestamp":1790935138259,"version":"4.1.0"},"reference-count":87,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,12,19]],"date-time":"2003-12-19T00:00:00Z","timestamp":1071792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2004,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Highly efficient and selective catalysts for the asymmetric reduction of aryl alkyl ketones under hydrogen\u2010transfer conditions (2\u2010propanol) were obtained by combining a novel class of pseudo\u2010dipeptide ligands with [{RuCl<jats:sub>2<\/jats:sub>(<jats:italic>p\u2010<\/jats:italic>cymene)}<jats:sub>2<\/jats:sub>]. A library of 36 dipeptide\u2010like ligands was prepared from <jats:italic>N<\/jats:italic>\u2010Boc\u2010protected \u03b1\u2010amino acids and the enantiomers of 2\u2010amino\u20101\u2010phenylethanol and 1\u2010amino\u20102\u2010propanol. The catalyst library was evaluated with the reduction of acetophenone and excellent enantioselectivity of 1\u2010phenylethanol was obtained with several of the novel catalysts. A ligand based on the combination of <jats:italic>N<\/jats:italic>\u2010Boc\u2010<jats:sc>L<\/jats:sc>\u2010alanine and (<jats:italic>S<\/jats:italic>)\u20101\u2010amino\u20102\u2010propanol (ligand A<jats:bold>\u2010<\/jats:bold>(<jats:italic>S<\/jats:italic>)\u2010<jats:bold>4<\/jats:bold>) was found to be particular effective. When the situ formed ruthenium complex of this ligand was employed as the catalyst in the hydrogen\u2010transfer reaction of various aryl alkyl ketones, the corresponding alcohol products were achieved in excellent enantioselectivity (up to 98\u2009% <jats:italic>ee<\/jats:italic>).<\/jats:p>","DOI":"10.1002\/chem.200305553","type":"journal-article","created":{"date-parts":[[2003,12,19]],"date-time":"2003-12-19T15:00:38Z","timestamp":1071846038000},"page":"294-302","source":"Crossref","is-referenced-by-count":89,"title":["Highly Enantioselective Ruthenium\u2010Catalyzed Reduction of Ketones Employing Readily Available Peptide Ligands"],"prefix":"10.1002","volume":"10","author":[{"given":"Anders","family":"B\u00f8gevig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidro 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97\u2009%ee."},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0957-4166(01)00429-3"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(78)80197-5"},{"key":"e_1_2_6_67_2","unstructured":"A\u2010(rac)\u20104is the 1:1 diastereomeric mixture of ligands A\u2010(S)\u20104and A\u2010(R)\u20104. 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[4b]."}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchem.200305553","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.200305553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T15:41:58Z","timestamp":1760283718000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.200305553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,19]]},"references-count":87,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1,5]]}},"alternative-id":["10.1002\/chem.200305553"],"URL":"https:\/\/doi.org\/10.1002\/chem.200305553","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,19]]}}}