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Copper, iron, and zinc are the most abundant transition metals relevant to biological systems. In addition to their important biological functions, metals can also catalyze the formation of damaging free radical species. Hence, their intracellular transport is tightly regulated. Despite recent insights into the intracellular transport of copper and other metals, our overall understanding of intracellular metal metabolism remains incomplete and it is likely that many metal\u2010binding proteins remain undiscovered. Furthermore, the protein targets for metals during metal\u2010associated disease states or during exposure to toxic levels of environmental metals are yet to be unravelled. A proteomics strategy for the analysis of metal\u2010transporting or metal\u2010binding proteins has the potential to uncover how a large number of proteins function in normal or metal\u2010associated diseased states. Here we discuss the principal aspects of metal metabolism, and the recent developments in the area of the proteomics of metal transport.<\/jats:p>","DOI":"10.1002\/chem.200500664","type":"journal-article","created":{"date-parts":[[2005,8,31]],"date-time":"2005-08-31T06:49:51Z","timestamp":1125470991000},"page":"2410-2422","source":"Crossref","is-referenced-by-count":44,"title":["Proteomics of Metal Transport and Metal\u2010Associated Diseases"],"prefix":"10.1002","volume":"12","author":[{"given":"Prasad P.","family":"Kulkarni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Min","family":"She","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve A.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibudhendra","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr9500390"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M300080-MCP200"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200300557"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2002.02900.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200300476"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr049941r"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1201\/9780203909300"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1201\/9780203909300.ch8"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1201\/9780203909300.ch16"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R000006200"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006816321679"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.70.1.677"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00343-5"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-3148-y"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5339.853"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.02110s5695"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.09.013"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020709307589"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-003-0482-3"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00130-8"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/75534"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mog.0000153362.98276.db"},{"key":"e_1_2_6_23_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/bj3520241","author":"Cairo G.","year":"2000","journal-title":"Biochem. 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