{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:42:36Z","timestamp":1778812956702,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T00:00:00Z","timestamp":1137542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2006,3,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Helical polymers of isocyanopeptides derived from \u03b2\u2010amino acids have been synthesized and their architectures have been studied in detail. Similar to their \u03b1\u2010amino acid analogues, the helical conformation in these macromolecules is stabilized by internal hydrogen\u2010bonding arrays along the polymeric backbone. Unexpectedly, the flexibility of the \u03b2\u2010peptide side arms results in a rearrangement of the initial macromolecular architecture, leading to a more stable helical structure possessing a better defined hydrogen\u2010bonding pattern, as was concluded from IR and temperature\u2010dependent circular dichroism studies. Based on these results we propose a dynamic helical model for the \u03b2\u2010amino acid derived polyisocyanopeptides; this model is in contrast to the kinetically stable helical macromolecules that are formed upon polymerization of \u03b1\u2010amino acid based isocyanopeptides.<\/jats:p>","DOI":"10.1002\/chem.200501042","type":"journal-article","created":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T06:16:53Z","timestamp":1137565013000},"page":"2778-2786","source":"Crossref","is-referenced-by-count":28,"title":["Synthesis, Characterization, and Folding Behavior of \u03b2\u2010Amino Acid Derived Polyisocyanides"],"prefix":"10.1002","volume":"12","author":[{"given":"Sander J.","family":"Wezenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald A.","family":"Metselaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan E.","family":"Rowan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen J. L. M.","family":"Cornelissen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Seebach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roeland J. M.","family":"Nolte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,10]]},"reference":[{"key":"e_1_2_6_1_2","volume-title":"Introduction to Protein Structure","author":"Branden C.","year":"1999"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr990120t"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr0000978"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(76)80097-X"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00179a002"},{"key":"e_1_2_6_6_2","unstructured":"\u00a0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/cs9942300011"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr990126i"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma60008a003"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/pol.1968.150060601"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/recl.19730920109"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma00184a051"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0518(199702)35:3<439::AID-POLA6>3.0.CO;2-N"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma00097a010"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062224"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma011946b"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200490087"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr000045i"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19770890423"},{"key":"e_1_2_6_19_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.197702591"},{"key":"e_1_2_6_20_2","unstructured":"\u00a0"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19960790402"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3757(19990601)111:11<1700::AID-ANGE1700>3.0.CO;2-M"},{"key":"e_1_2_6_22_3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19990601)38:11<1595::AID-ANIE1595>3.0.CO;2-0"},{"key":"e_1_2_6_23_2","unstructured":"\u00a0"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3927(19980701)19:7<359::AID-MARC359>3.0.CO;2-T"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/34384"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/pola.10083"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma048786z"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma00245a001"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/pola.10713"},{"key":"e_1_2_6_30_2","unstructured":"\u00a0"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja974048x"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja016393z"},{"key":"e_1_2_6_33_2","unstructured":"G. A. Metselaar J. J. L. M. Cornelissen A. E. Rowan R. J. M. Nolte unpublished results."},{"key":"e_1_2_6_34_2","unstructured":"\u00a0"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0259537"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja039279k"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchem.200501042","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.200501042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:16:04Z","timestamp":1760267764000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.200501042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,10]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,3,20]]}},"alternative-id":["10.1002\/chem.200501042"],"URL":"https:\/\/doi.org\/10.1002\/chem.200501042","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,10]]}}}