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A few exceptions have been encountered in which tetrasubstituted cyclopentanols or pentasubstituted 1,4\u2010cyclohexanediols were selectively formed. The use of 2\u2010iodoethoxycarbene complexes gave access to 1,2,4\u2010cyclohexanetriols. These multicomponent\u2010coupling reactions involved the formation of lithium alkylpentacarbonylchromates as key intermediates, which further evolved through intramolecular processes, such as insertion of an alkene, CO insertion or addition to a carbonyl group, and, moreover, could be trapped in intermolecular reactions with different electrophiles and styrene. The substitution pattern of the alkylchromate carbon chain has been proposed to control the nature of the annulation process.<\/jats:p>","DOI":"10.1002\/chem.200600491","type":"journal-article","created":{"date-parts":[[2006,8,22]],"date-time":"2006-08-22T15:49:48Z","timestamp":1156261788000},"page":"7225-7235","source":"Crossref","is-referenced-by-count":17,"title":["Diastereoselective Multicomponent Cyclizations of Fischer Carbene Complexes, Lithium Enolates, and Allylmagnesium Bromide Leading to Highly Substituted Five\u2010 and Six\u2010Membered Carbocycles"],"prefix":"10.1002","volume":"12","author":[{"given":"Jos\u00e9","family":"Barluenga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n","family":"P\u00e9rez\u2010S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos G.","family":"Suero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefa","family":"Fl\u00f3rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,6]]},"reference":[{"key":"e_1_2_6_1_2","volume-title":"Metal Carbenes in Organic Synthesis, Vol. 13: Topics Organomet. 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