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CP mainly adopts the 1,3\u2010alternate conformation in all the solvents, although the percentage of alternative conformations increases in polar solvents, especially those with good hydrogen\u2010bonding acceptor properties. However, in the case of 8F\u2010CP, the cone conformation is the most populated in some solvents. Transitions between conformers are common and fast, and both CP and 8F\u2010CP can adopt the cone conformation needed for optimum interaction with anions more easily than would be predicted on the basis of previous gas\u2010phase calculations. Furthermore, the present studies show that when a fluoride anion is specifically placed initially in close proximity to CP and 8F\u2010CP in their respective 1,3\u2010alternate conformations, an extremely fast change to the cone conformation is observed in both cases. The results suggest that preorganization does not represent a major impediment to anion\u2010binding for either CP or 8F\u2010CP, and that ion\u2010induced conformational changes can follow different mechanisms depending on the solvent and the chemical substituents present on the calix[4]pyrrole beta\u2010pyrrolic positions.<\/jats:p>","DOI":"10.1002\/chem.200600757","type":"journal-article","created":{"date-parts":[[2006,11,6]],"date-time":"2006-11-06T07:28:29Z","timestamp":1162798109000},"page":"1108-1116","source":"Crossref","is-referenced-by-count":38,"title":["Exploring the Dynamics of Calix[4]pyrrole: Effect of Solvent and Fluorine Substitution"],"prefix":"10.1002","volume":"13","author":[{"given":"J.\u2005Ram\u00f3n","family":"Blas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Maria","family":"L\u00f3pez\u2010Bes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"M\u00e1rquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan\u2005L.","family":"Sessler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.\u2005Javier","family":"Luque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Modesto","family":"Orozco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,9]]},"reference":[{"key":"e_1_2_5_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja051421p"},{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8511582"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-3973-1"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr960386p"},{"key":"e_1_2_5_5_2","volume-title":"Supramolecular Chemistry of Anions","author":"Bianchi A.","year":"1997"},{"key":"e_1_2_5_6_2","first-page":"10","volume":"36","author":"Schmidtchen F. 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