{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:18:10Z","timestamp":1790378290846,"version":"4.1.0"},"reference-count":113,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,10,13]],"date-time":"2006-10-13T00:00:00Z","timestamp":1160697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A highly enantioselective Michael addition of \u03b1\u2010substituted cyanoacetates to vinyl ketones was accomplished in the presence of simple bifunctional thiourea\/tertiary amine organocatalysts. A number of \u03b1\u2010aryl or alkyl cyanoacetates have been successfully applied to give multifunctional compounds with an all\u2010carbon\u2010substituted quaternary stereocenter in excellent enantioselectivities (82\u201397\u2009% <jats:italic>ee<\/jats:italic>) and yields (61\u201399\u2009%). The optical pure adducts could be smoothly converted to variously structured \u03b2<jats:sup>2,2<\/jats:sup>\u2010amino acid esters. Moreover, an interesting reaction model involving multiple hydrogen\u2010bonding interactions amongst the thiourea\/tertiary amine catalyst and the reactants has been proposed based on the absolute configuration of the adduct and computational studies.<\/jats:p>","DOI":"10.1002\/chem.200600796","type":"journal-article","created":{"date-parts":[[2006,10,13]],"date-time":"2006-10-13T17:09:45Z","timestamp":1160759385000},"page":"319-327","source":"Crossref","is-referenced-by-count":82,"title":["Enantioselective Michael Addition of \u03b1\u2010Substituted Cyanoacetates to Vinyl Ketones Catalyzed by Bifunctional Organocatalysts"],"prefix":"10.1002","volume":"13","author":[{"given":"Tian\u2010Yu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bang\u2010Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Sheng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,11]]},"reference":[{"key":"e_1_2_6_1_2","unstructured":"For recent reviews see:"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(02)00991-2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200301600"},{"key":"e_1_2_6_3_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200301600"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200301692"},{"key":"e_1_2_6_4_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200301692"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0690(200001)2000:1<1::AID-EJOC1>3.0.CO;2-6"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","volume-title":"Asymmetric Catalysis in Enantioselective Synthesis of \u03b2\u2010Amino Acids","author":"Wenzel A. 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