{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:41:08Z","timestamp":1760269268901,"version":"build-2065373602"},"reference-count":70,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2007,8,17]],"date-time":"2007-08-17T00:00:00Z","timestamp":1187308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2007,11,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chromium alkoxy alkynyl Fischer carbene complexes react with symmetrical internal alkynes to form new and different organometallic species, which result from consecutive insertions of several alkyne units and carbonyl groups into the metal\u2013carbon bond. The insertion sequence can be controlled and, by slight modification of the reaction conditions, it can be directed to the preparation of either seven\u2010 or five\u2010component adducts. Three molecules of alkyne, two carbonyl groups, the carbene ligand and the chromium metal moiety partake in the creation of seven new carbon\u2013carbon bonds and two five\u2010membered carbocycles in the first case while four new carbon\u2013carbon bonds, a \u03c3 Cr\uf8ffC(sp<jats:sup>2<\/jats:sup>) bond and a cyclopentadienyl moiety are built in the second case. Evidence that five\u2010component chromium complexes are intermediates in the formation of seven\u2010component adducts is provided; they are also able to insert a unit of a different internal alkyne which confers more diversity to the seven\u2010component adducts. The presence of the \u03c3 Cr\uf8ffC(sp<jats:sup>2<\/jats:sup>) bond has also been exploited to develop the synthesis of both cyclopentene\u2010fused and novel spiro\u2010cyclopentenones as well as symmetrical biscyclopentenones. Finally, the isolation of six\u2010component adducts, when tolane was employed as the initial alkyne, provides further support to the proposed mechanism.<\/jats:p>","DOI":"10.1002\/chem.200700776","type":"journal-article","created":{"date-parts":[[2007,8,17]],"date-time":"2007-08-17T12:48:19Z","timestamp":1187354899000},"page":"9115-9126","source":"Crossref","is-referenced-by-count":10,"title":["Up to Seven\u2010Component Adducts by Unprecedented Multiple Alkyne and Carbonyl Insertions in the Metal\u2013Carbon Bond of Chromium Alkoxy Alkynyl Carbene Complexes"],"prefix":"10.1002","volume":"13","author":[{"given":"Jos\u00e9","family":"Barluenga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Garc\u00eda\u2010Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel\u2005A.","family":"Fern\u00e1ndez\u2010Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Rocaboy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Facundo","family":"Andina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Merino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,24]]},"reference":[{"key":"e_1_2_6_1_2","unstructured":"\u00a0"},{"volume-title":"Multicomponent Reactions","year":"2005","key":"e_1_2_6_2_2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200460548"},{"key":"e_1_2_6_3_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200460548"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200390167"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867033368600"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1351\/pac200173010187"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1128(200007)20:4<304::AID-MED3>3.0.CO;2-8"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3757(20000915)112:18<3300::AID-ANGE3300>3.0.CO;2-Z"},{"key":"e_1_2_6_8_3","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO;2-U"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3765(20000915)6:18<3321::AID-CHEM3321>3.0.CO;2-A"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2174\/0929867306666220208210120","volume":"6","author":"Dax S. 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