{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T17:54:30Z","timestamp":1770573270844,"version":"3.49.0"},"reference-count":74,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2008,4,28]],"date-time":"2008-04-28T00:00:00Z","timestamp":1209340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2008,6,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>For the synthesis of a 12\u2010membered salicylic macrolide scaffold, ring\u2010closing metathesis (RCM) of a \u03c9\u2010diene compound was planned. The stereochemical outcome of the RCM reaction changed depending on the type of Ru catalyst that was used; a \u201cfirst\u2010generation\u201d Grubbs catalyst produced exclusively the <jats:italic>E<\/jats:italic> isomer and \u201csecond\u2010generation\u201d catalysts provided a mixture of the <jats:italic>E<\/jats:italic> and <jats:italic>Z<\/jats:italic> isomers under kinetic control (not thermodynamic control). Considerations for the <jats:italic>E<\/jats:italic>\/<jats:italic>Z<\/jats:italic> selectivity are described.<\/jats:p>","DOI":"10.1002\/chem.200800249","type":"journal-article","created":{"date-parts":[[2008,4,28]],"date-time":"2008-04-28T11:50:16Z","timestamp":1209383416000},"page":"5275-5281","source":"Crossref","is-referenced-by-count":17,"title":["Kinetically Controlled Ring\u2010Closing Metathesis: Synthesis of a Potential Scaffold for 12\u2010Membered Salicylic Macrolides"],"prefix":"10.1002","volume":"14","author":[{"given":"Yuji","family":"Matsuya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho\u2010ichi","family":"Takayanagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Nemoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,5,29]]},"reference":[{"key":"e_1_2_5_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr030035s"},{"key":"e_1_2_5_2_2","unstructured":"\u00a0"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo971556g"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo9814997"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)29517-3"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867033457827"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.51.14"},{"key":"e_1_2_5_8_2","unstructured":"For 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proposal is not necessarily in agreement with the past theoretical studies but most likely rationalizes the experimental results obtained here. We would like to emphasize that this hypothesis is not applied in general but is limited to our present reaction system because the relative energy levels of RCM intermediates can be substrate dependent."},{"key":"e_1_2_5_61_2","unstructured":"In the overall RCM process a rate\u2010determining step for the second\u2010generation catalysts has been reported to be a phosphine\u2010dissociation step. 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