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By using <jats:bold>1\u2009b<\/jats:bold> and <jats:bold>1\u2009c<\/jats:bold> as a racemic mixture, complexes <jats:bold>4<\/jats:bold>\u2013<jats:bold>7<\/jats:bold> were obtained through a diastereoselective synthesis promoted by acetic acid. These pincer complexes, which display correctly matched chiral PP and CNN ligands, are remarkably active catalysts for the asymmetric reduction of alkyl aryl ketones in basic alcohol media by both transfer hydrogenation (TH) and hydrogenation (HY), achieving enantioselectivities of up to 99\u2009%. In 2\u2010propanol, the enantioselective TH of ketones was accomplished by using a catalyst loading as low as 0.002\u2005mol\u2009% and afforded a turnover frequency (TOF) of 10<jats:sup>5<\/jats:sup>\u201310<jats:sup>6<\/jats:sup>\u2005h<jats:sup>\u22121<\/jats:sup> (60 and 82\u2009\u00b0C). In methanol\/ethanol mixtures, the CNN pincer complexes catalyzed the asymmetric HY of ketones with H<jats:sub>2<\/jats:sub> (5\u2005atm) at 0.01\u2005mol\u2009% relative to the complex with a TOF of \u224810<jats:sup>4<\/jats:sup>\u2005h<jats:sup>\u22121<\/jats:sup> at 40\u2009\u00b0C.<\/jats:p>","DOI":"10.1002\/chem.200802112","type":"journal-article","created":{"date-parts":[[2008,12,3]],"date-time":"2008-12-03T03:30:17Z","timestamp":1228275017000},"page":"726-732","source":"Crossref","is-referenced-by-count":101,"title":["Highly Productive CNN Pincer Ruthenium Catalysts for the Asymmetric Reduction of Alkyl Aryl Ketones"],"prefix":"10.1002","volume":"15","author":[{"given":"Walter","family":"Baratta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Chelucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santo","family":"Magnolia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Siega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Rigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,29]]},"reference":[{"key":"e_1_2_6_1_2","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","volume-title":"New Frontiers in Asymmetric Catalysis","year":"2007"},{"key":"e_1_2_6_3_2","volume-title":"Asymmetric Catalysis on Industrial Scale","year":"2004"},{"key":"e_1_2_6_4_2","unstructured":"\u00a0"},{"key":"e_1_2_6_5_2","volume-title":"The Handbook of Homogeneous Hydrogenation, Vols.\u20051\u20133","year":"2007"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.200390000"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3757(20010105)113:1<40::AID-ANGE40>3.0.CO;2-K"},{"key":"e_1_2_6_7_3","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20010105)40:1<40::AID-ANIE40>3.0.CO;2-5"},{"key":"e_1_2_6_8_2","unstructured":"\u00a0"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.200800498"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar700134q"},{"key":"e_1_2_6_11_2","first-page":"11","volume":"25","author":"Morris D. 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