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Continuous regeneration of the achiral starting material is effected via selective enzyme\u2010catalyzed hydrolysis of the minor product enantiomer from Lewis acid\u2013Lewis base catalyzed addition of acyl cyanides to prochiral aldehydes in a two\u2010phase solvent system. The process provides O\u2010acylated cyanohydrins in close to perfect enantioselectivities, higher than those obtained in the direct process, and in high yields. A combination of a (<jats:italic>S<\/jats:italic>,<jats:italic>S<\/jats:italic>)\u2010salen Ti Lewis acid and <jats:italic>Candida antarctica<\/jats:italic> lipase B provides the products with <jats:italic>R<\/jats:italic> absolute configuration, whereas the opposite enantiomer is obtained from the (<jats:italic>R<\/jats:italic>,<jats:italic>R<\/jats:italic>)\u2010salen Ti complex and <jats:italic>Candida rugosa<\/jats:italic> lipase.<\/jats:p>","DOI":"10.1002\/chem.200901338","type":"journal-article","created":{"date-parts":[[2009,9,18]],"date-time":"2009-09-18T10:52:19Z","timestamp":1253271139000},"page":"12107-12113","source":"Crossref","is-referenced-by-count":43,"title":["Minor Enantiomer Recycling: Metal Catalyst, Organocatalyst and Biocatalyst Working in 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