{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:33:49Z","timestamp":1788431629156,"version":"build-2803163510"},"reference-count":66,"publisher":"Wiley","issue":"41","license":[{"start":{"date-parts":[[2009,9,8]],"date-time":"2009-09-08T00:00:00Z","timestamp":1252368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2009,10,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The first highly enantioselective phosphonylation of \u03b1,\u03b2\u2010unsaturated <jats:italic>N<\/jats:italic>\u2010acylpyrroles has been developed. Excellent yields (91\u201399\u2009%) and enantioselectivities (up to &gt;99\u2009% enantiomeric excess (<jats:italic>ee<\/jats:italic>)) were observed for a broad spectrum of both phosphites and <jats:italic>N<\/jats:italic>\u2010acylpyrroles under mild conditions. In particular, when diethyl phosphite was employed to test the scope of the <jats:italic>N<\/jats:italic>\u2010acylpyrroles, almost optically pure products (98 to &gt;99\u2009%\u2005<jats:italic>ee<\/jats:italic>) were obtained for 20 examples of <jats:italic>N<\/jats:italic>\u2010acylpyrroles. Moreover, optically pure \u03b1\u2010substituted \u03b2\u2010 or \u03b3\u2010amino phosphonates can be obtained by several simple transformations of the pyrrolyl phosphonates. The versatility of the <jats:italic>N<\/jats:italic>\u2010acylpyrrole moiety makes the phosphorus adducts powerful chiral building blocks that enable the synthesis of various phosphonate\u2010containing compounds. Finally, the present strategy can also be applied to the asymmetric hydrophosphonylation of <jats:italic>N<\/jats:italic>\u2010acylimines with high enantioselectivities (93 to &gt;99\u2009%\u2005<jats:italic>ee<\/jats:italic>).<\/jats:p>","DOI":"10.1002\/chem.200901901","type":"journal-article","created":{"date-parts":[[2009,9,8]],"date-time":"2009-09-08T14:49:21Z","timestamp":1252421361000},"page":"10983-10987","source":"Crossref","is-referenced-by-count":78,"title":["Highly Enantioselective Conjugate Additions of Phosphites to \u03b1,\u03b2\u2010Unsaturated <i>N<\/i>\u2010Acylpyrroles and Imines: A Practical Approach to Enantiomerically Enriched Amino Phosphonates"],"prefix":"10.1002","volume":"15","author":[{"given":"Depeng","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,10,13]]},"reference":[{"key":"e_1_2_6_1_2","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","volume-title":"The Role of Phosphonates in Living 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