{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:04:00Z","timestamp":1791158640882,"version":"4.1.0"},"reference-count":118,"publisher":"Wiley","issue":"46","license":[{"start":{"date-parts":[[2009,10,28]],"date-time":"2009-10-28T00:00:00Z","timestamp":1256688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2009,11,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Biofuel cells with a switchable power release controlled by biochemical signals, which can be logically processed by biomolecular computing systems, have been designed. The switchable properties of the biofuel cells were based on the polymer\u2010brush\u2010modified electrodes with the activity dependent on the solution pH value. The pH changes generated in situ by biocatalytic reactions allowed the reversible activation\u2014inactivation of the bioelectrocatalytic interfaces\u2014thus affecting the activity of the entire biofuel cells. Boolean logic operations performed by either enzyme\u2010 or immune\u2010based systems were functionally integrated with the switchable biocatalytic process allowing logic control over them. Scaling up the complexity of the biocomputing systems to complex multi\u2010component logic networks with a built\u2010in \u201cprogram\u201d resulted in the control of the bioelectronic systems by multi\u2010signal patterns of biochemical inputs. Future implantable biofuel cells producing electrical power on\u2010demand depending on physiological conditions are feasible, as the result of the present research.<\/jats:p>","DOI":"10.1002\/chem.200902367","type":"journal-article","created":{"date-parts":[[2009,10,29]],"date-time":"2009-10-29T16:33:22Z","timestamp":1256834002000},"page":"12554-12564","source":"Crossref","is-referenced-by-count":96,"title":["Biofuel Cells Controlled by Logically Processed Biochemical Signals: Towards Physiologically Regulated Bioelectronic Devices"],"prefix":"10.1002","volume":"15","author":[{"given":"Evgeny","family":"Katz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Pita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,11,18]]},"reference":[{"key":"e_1_2_7_1_2","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","volume-title":"Handbook of Fuel Cells\u2014Fundamentals, Technology, Applications","year":"2003"},{"key":"e_1_2_7_3_2","volume-title":"Fuel Cell Fundamentals","author":"O\u2019Hayre R.","year":"2009"},{"key":"e_1_2_7_4_2","unstructured":"\u00a0"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2009.SI03"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2006.04.029"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2006.01.030"},{"key":"e_1_2_7_8_2","first-page":"455","volume":"73","author":"Shukla A. K.","year":"2004","journal-title":"Curr. Sci."},{"key":"e_1_2_7_9_2","first-page":"355","volume-title":"Handbook of Fuel Cells\u2014Fundamentals, Technology, Applications, Part\u20054, Vol.\u20051","author":"Katz E.","year":"2003"},{"key":"e_1_2_7_10_2","unstructured":"\u00a0"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp802099p"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp805092m"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/app.25928"},{"key":"e_1_2_7_14_2","unstructured":"\u00a0"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.elecom.2008.04.025"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2007.11.004"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.elecom.2006.08.024"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp055654e"},{"key":"e_1_2_7_19_2","unstructured":"\u00a0"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1039\/b809009b"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr0680639"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2007.03.007"},{"key":"e_1_2_7_23_2","first-page":"1530","volume":"18","author":"Liu Q.","year":"2006","journal-title":"Prog. Chem."},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2005.11.006"},{"key":"e_1_2_7_25_2","unstructured":"\u00a0"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1039\/b810642h"},{"key":"e_1_2_7_27_2","first-page":"1233","volume":"20","author":"Lu N.","year":"2008","journal-title":"Prog. Chem."},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2007.05.004"},{"key":"e_1_2_7_29_2","first-page":"74","volume":"19","author":"Yi G.","year":"2007","journal-title":"Prog. Chem."},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2006.10.003"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/es0605016"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt867"},{"key":"e_1_2_7_33_2","unstructured":"\u00a0"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3757(20000403)112:7<1230::AID-ANGE1230>3.0.CO;2-3"},{"key":"e_1_2_7_34_3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(20000403)39:7<1180::AID-ANIE1180>3.0.CO;2-E"},{"key":"e_1_2_7_35_2","first-page":"559","volume-title":"Encyclopedia of Electrochemistry, Vol.\u20059","author":"Katz E.","year":"2002"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9797(03)00148-6"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/j100188a007"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/elan.1140090902"},{"key":"e_1_2_7_39_2","unstructured":"\u00a0"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.elecom.2006.05.024"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.electacta.2006.03.050"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2004.08.032"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2004.08.017"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1149\/1.1592519"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-0728(99)00425-8"},{"key":"e_1_2_7_46_2","unstructured":"\u00a0"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1039\/b801786g"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.elecom.2007.01.055"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1039\/b703627m"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/elan.200603621"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1021\/es052254w"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelechem.2004.08.014"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1039\/b408411j"},{"key":"e_1_2_7_54_2","unstructured":"\u00a0"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.elecom.2008.03.010"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1039\/b708013c"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioelechem.2005.03.002"},{"key":"e_1_2_7_58_2","unstructured":"\u00a0"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.elecom.2008.03.019"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.electacta.2007.01.067"},{"key":"e_1_2_7_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2006.04.019"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/elan.200603626"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200400275"},{"key":"e_1_2_7_64_2","doi-asserted-by":"publisher","DOI":"10.1039\/b313149a"},{"key":"e_1_2_7_65_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr020719k"},{"key":"e_1_2_7_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-006-0326-4"},{"key":"e_1_2_7_67_2","unstructured":"\u00a0"},{"key":"e_1_2_7_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/elan.200804441"},{"key":"e_1_2_7_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0956-5663(97)00038-9"},{"key":"e_1_2_7_70_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn700214f"},{"key":"e_1_2_7_71_2","doi-asserted-by":"publisher","DOI":"10.1071\/CH03307"},{"key":"e_1_2_7_72_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja034008v"},{"key":"e_1_2_7_73_2","unstructured":"\u00a0"},{"key":"e_1_2_7_74_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00129a023"},{"key":"e_1_2_7_75_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl0350783"},{"key":"e_1_2_7_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/347658a0"},{"key":"e_1_2_7_77_2","unstructured":"\u00a0"},{"key":"e_1_2_7_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2006.04.031"},{"key":"e_1_2_7_79_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4095(20021104)14:21<1549::AID-ADMA1549>3.0.CO;2-C"},{"key":"e_1_2_7_80_2","unstructured":"\u00a0"},{"key":"e_1_2_7_81_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja042910c"},{"key":"e_1_2_7_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3765(20020916)8:18<4138::AID-CHEM4138>3.0.CO;2-Z"},{"key":"e_1_2_7_83_2","doi-asserted-by":"publisher","DOI":"10.1039\/b708313k"},{"key":"e_1_2_7_84_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200604082"},{"key":"e_1_2_7_84_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200604082"},{"key":"e_1_2_7_85_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp801086w"},{"key":"e_1_2_7_86_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-008-3579-y"},{"key":"e_1_2_7_87_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja8043882"},{"key":"e_1_2_7_88_2","unstructured":"\u00a0"},{"key":"e_1_2_7_89_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200700762"},{"key":"e_1_2_7_90_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp0568327"},{"key":"e_1_2_7_91_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200503314"},{"key":"e_1_2_7_91_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200503314"},{"key":"e_1_2_7_92_2","unstructured":"\u00a0"},{"key":"e_1_2_7_93_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja7114713"},{"key":"e_1_2_7_94_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608319103"},{"key":"e_1_2_7_95_2","unstructured":"\u00a0"},{"key":"e_1_2_7_96_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja8088108"},{"key":"e_1_2_7_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioelechem.2009.06.012"},{"key":"e_1_2_7_98_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja8076704"},{"key":"e_1_2_7_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioelechem.2009.03.008"},{"key":"e_1_2_7_100_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9048459"},{"key":"e_1_2_7_101_2","doi-asserted-by":"publisher","DOI":"10.1007\/b11268"},{"key":"e_1_2_7_102_2","unstructured":"\u00a0"},{"key":"e_1_2_7_103_2","doi-asserted-by":"publisher","DOI":"10.1080\/15583720600945402"},{"key":"e_1_2_7_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2004.03.001"},{"key":"e_1_2_7_105_2","unstructured":"\u00a0"},{"key":"e_1_2_7_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2009.05.019"},{"key":"e_1_2_7_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2009.03.001"},{"key":"e_1_2_7_108_2","volume-title":"Programmable Logic Devices. Technology and Applications","author":"Bostock G.","year":"1988"},{"key":"e_1_2_7_109_2","first-page":"55","volume":"29","author":"Bartlett P. N.","year":"1991","journal-title":"Prog. React. Kinet."},{"key":"e_1_2_7_110_2","unstructured":"\u00a0"},{"key":"e_1_2_7_111_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp904585x"},{"key":"e_1_2_7_112_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp810743w"},{"key":"e_1_2_7_113_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp802673q"},{"key":"e_1_2_7_114_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp905620c"},{"key":"e_1_2_7_115_2","doi-asserted-by":"publisher","DOI":"10.1021\/am900185c"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchem.200902367","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.200902367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T09:14:05Z","timestamp":1760260445000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.200902367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,18]]},"references-count":118,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2009,11,23]]}},"alternative-id":["10.1002\/chem.200902367"],"URL":"https:\/\/doi.org\/10.1002\/chem.200902367","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,18]]}}}